Cell Biology Antibodies 4

Anti-DGCR2 Antibody (CAB14267)

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SKU:
CAB14267
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DGCR2 Antibody
Antibody SKU:CAB14267
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-200 of human DGCR2 (NP_005128.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-200 of human DGCR2 (NP_005128.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TEPL RPEL RCNP GQFA CRSG TIQC IPLP WQCD GWAT CEDE SDEA NCPE VTGE VRPH HGKE AVDP RQGR ARGG DPSH FHAV NVAQ PVRF SSFL GKCP TGWH HYEG TASC YRVY LSGE NYWD AAQT CQRL NGSL ATFS TDQE LRFV LAQE WDQP ERSF GWKD QRKL WVGY QYVI TGRN RSLE
Gene ID:9993
Uniprot:P98153
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:36kDa/56kDa/60kDa
Observed MW:61kDa
Synonyms:DGCR2, DGS-C, IDD, LAN, SEZ-12
Background:Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:DGCR2: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.21

Biological Process: cognition; organ morphogenesis

Disease: Velocardiofacial Syndrome

NCBI Summary:Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Code:P98153
NCBI GenInfo Identifier:1708396
NCBI Gene ID:9993
NCBI Accession:P98153.1
UniProt Secondary Accession:P98153,A6NIB5, A8K6K5, B5TY34, B7Z935,
UniProt Related Accession:P98153
Molecular Weight:36,713 Da
NCBI Full Name:Integral membrane protein DGCR2/IDD
NCBI Synonym Full Names:DiGeorge syndrome critical region gene 2
NCBI Official Symbol:DGCR2  
NCBI Official Synonym Symbols:IDD; LAN; DGS-C; SEZ-12  
NCBI Protein Information:integral membrane protein DGCR2/IDD
UniProt Protein Name:Integral membrane protein DGCR2/IDD
Protein Family:Integral membrane protein
UniProt Gene Name:DGCR2  
UniProt Entry Name:IDD_HUMAN
Anti-DGCR2 Antibody (CAB14267)Western blot analysis of extracts of various cell lines, using DGCR2 antibody (CAB14267) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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