Anti-Destrin Antibody (CAB19772)
- SKU:
- CAB19772
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ACTDP
- Synonyms:
- ADF
- Synonyms:
- HEL32
- Synonyms:
- bA462D18.2
- Research Area:
- Cell Biology
Description
| Product Name: | Destrin Rabbit mAb |
| Product Code: | CAB19772 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ACTDP, ADF, HEL32, bA462D18.2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Destrin |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, MCF7, NIH/3T3, C6, Mouse lung, Mouse spleen, Rat lung, Rat spleen |
| Immunogen: | A synthesized peptide derived from human Destrin |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11034 |
| Uniprot: | P60981 |
| Calculated MW: | 17kDa |
| Observed MW: | 19KDa |
| UniProt Protein Function: | Destrin: an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it's severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 20p12.1 Cellular Component: actin cytoskeleton Molecular Function:protein binding Biological Process: actin polymerization and/or depolymerization |
| NCBI Summary: | The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P60981 |
| NCBI GenInfo Identifier: | 46577586 |
| NCBI Gene ID: | 11034 |
| NCBI Accession: | P60981.3 |
| UniProt Secondary Accession: | P60981,P18282, Q5W166, Q6IAW2, B2R6N2, B4DYA6, |
| UniProt Related Accession: | P60981 |
| Molecular Weight: | 16,621 Da |
| NCBI Full Name: | Destrin |
| NCBI Synonym Full Names: | destrin, actin depolymerizing factor |
| NCBI Official Symbol: | DSTN |
| NCBI Official Synonym Symbols: | ADF; ACTDP; HEL32; bA462D18.2 |
| NCBI Protein Information: | destrin |
| UniProt Protein Name: | Destrin |
| UniProt Synonym Protein Names: | Actin-depolymerizing factor; ADF |
| Protein Family: | Destrin |
| UniProt Gene Name: | DSTN |
| UniProt Entry Name: | DEST_HUMAN |
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