Cell Biology Antibodies 12
Anti-Desmoglein-3 Antibody (CAB8412)
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- SKU:
- CAB8412
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Desmoglein-3 Antibody |
| Antibody SKU: | CAB8412 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 749-999 of human DSG3 (NP_001935.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 749-999 of human DSG3 (NP_001935.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FGAA TGVG ICSS GQSG TMRT RHST GGTN KDYA DGAI SMNF LDSY FSQK AFAC AEED DGQE ANDC LLIY DNEG ADAT GSPV GSVG CCSF IADD LDDS FLDS LGPK FKKL AEIS LGVD GEGK EVQP PSKD SGYG IESC GHPI EVQQ TGFV KCQT LSGS QGAS ALST SGSV QPAV SIPD PLQH GNYL VTET YSAS GSLV QPST AGFD PLLT QNVI VTER VICP ISSV PGNL AGPT QLRG SHTM LCTE DPCS RLI |
| Gene ID: | 1830 |
| Uniprot: | P32926 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome |
| Calculated MW: | 107kDa |
| Observed MW: | 108kDa |
| Synonyms: | DSG3, CDHF6, PVA |
| Background: | This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. |
| UniProt Protein Function: | DSG3: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 18q12.1 Cellular Component: desmosome; plasma membrane; integral to membrane; cytosol Molecular Function:calcium ion binding Biological Process: apoptosis; homophilic cell adhesion; cell structure disassembly during apoptosis |
| NCBI Summary: | Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32926 |
| NCBI GenInfo Identifier: | 239938621 |
| NCBI Gene ID: | 1830 |
| NCBI Accession: | P32926.2 |
| UniProt Secondary Accession: | P32926,A8K2V2, |
| UniProt Related Accession: | P32926 |
| Molecular Weight: | 107,533 Da |
| NCBI Full Name: | Desmoglein-3 |
| NCBI Synonym Full Names: | desmoglein 3 |
| NCBI Official Symbol: | DSG3 |
| NCBI Official Synonym Symbols: | PVA; CDHF6 |
| NCBI Protein Information: | desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen |
| UniProt Protein Name: | Desmoglein-3 |
| UniProt Synonym Protein Names: | 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6 |
| Protein Family: | Desmoglein |
| UniProt Gene Name: | DSG3 |
| UniProt Entry Name: | DSG3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DSG3 antibody (CAB8412) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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