Cell Biology Antibodies 17
Anti-Desmoglein 3 Antibody (CAB5227)
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- SKU:
- CAB5227
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Desmoglein 3 Antibody |
| Antibody SKU: | CAB5227 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Desmoglein 3 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-431, Cal-27 |
| Immunogen: | A synthesized peptide derived from human Desmoglein 3 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1830 |
| Uniprot: | P32926 |
| Cellular Location: | |
| Calculated MW: | 145kDa |
| Observed MW: | 145KDa |
| Synonyms: | CDHF6, PVA |
| Background: | This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016] |
| UniProt Protein Function: | DSG3: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 18q12.1 Cellular Component: desmosome; plasma membrane; integral to membrane; cytosol Molecular Function:calcium ion binding Biological Process: apoptosis; homophilic cell adhesion; cell structure disassembly during apoptosis |
| NCBI Summary: | Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32926 |
| NCBI GenInfo Identifier: | 239938621 |
| NCBI Gene ID: | 1830 |
| NCBI Accession: | P32926.2 |
| UniProt Secondary Accession: | P32926,A8K2V2, |
| UniProt Related Accession: | P32926 |
| Molecular Weight: | 107,533 Da |
| NCBI Full Name: | Desmoglein-3 |
| NCBI Synonym Full Names: | desmoglein 3 |
| NCBI Official Symbol: | DSG3 |
| NCBI Official Synonym Symbols: | PVA; CDHF6 |
| NCBI Protein Information: | desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen |
| UniProt Protein Name: | Desmoglein-3 |
| UniProt Synonym Protein Names: | 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6 |
| Protein Family: | Desmoglein |
| UniProt Gene Name: | DSG3 |
| UniProt Entry Name: | DSG3_HUMAN |
 | Western blot - Desmoglein 3 Rabbit mAb (CAB5227) |
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