Cell Biology Antibodies 17
Anti-Desmin Antibody (CAB3736)
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- SKU:
- CAB3736
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Desmin Antibody |
| Antibody SKU: | CAB3736 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Desmin |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | C2C12, RD, Mouse lung, Mouse heart, Rat heart |
| Immunogen: | A synthesized peptide derived from human Desmin |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1674 |
| Uniprot: | P17661 |
| Cellular Location: | Cell membrane, Cytoplasm, sarcolemma |
| Calculated MW: | 53kDa |
| Observed MW: | 54KDa |
| Synonyms: | CSM1, CSM2, LGMD2R |
| Background: | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q35 Cellular Component: intermediate filament; fascia adherens; cytosol; neuromuscular junction; Z disc; sarcolemma Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding Disease: Cardiomyopathy, Dilated, 1i; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type; Myopathy, Myofibrillar, 1; Muscular Dystrophy, Limb-girdle, Type 2r |
| NCBI Summary: | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17661 |
| NCBI GenInfo Identifier: | 6686280 |
| NCBI Gene ID: | 1674 |
| NCBI Accession: | P17661.3 |
| UniProt Secondary Accession: | P17661,Q15787, Q549R7, Q549R8, Q549R9, Q8IZR1, Q8IZR6 Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, |
| UniProt Related Accession: | P17661 |
| Molecular Weight: | |
| NCBI Full Name: | Desmin |
| NCBI Synonym Full Names: | desmin |
| NCBI Official Symbol: | DES |
| NCBI Official Synonym Symbols: | CSM1; CSM2; LGMD2R |
| NCBI Protein Information: | desmin; mutant desmin p.K241E; intermediate filament protein |
| UniProt Protein Name: | Desmin |
| Protein Family: | Desmin |
| UniProt Gene Name: | DES |
| UniProt Entry Name: | DESM_HUMAN |
 | Western blot - Desmin Rabbit mAb (CAB3736) |
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