Cell Biology Antibodies 13

Anti-DENND5A Antibody (CAB17662)

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SKU:
CAB17662
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DENND5A Antibody
Antibody SKU:CAB17662
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1150-1240 of human DENND5A (NP_056028.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1150-1240 of human DENND5A (NP_056028.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AFQH GFKS PRLF KNVF IWDF LEKA QTYY ETLE KNEV VPEE NWHT RARN FCRF VTAI NNTP RNIG KDGK FQML VCLG ARDH LLHH WIAL LAD
Gene ID:23258
Uniprot:Q6IQ26
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:EIEE49, RAB6IP1, DENND5A
Background:This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017]
UniProt Protein Function:Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth.
NCBI Summary:This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017]
UniProt Code:Q6IQ26
NCBI GenInfo Identifier:343098489
NCBI Gene ID:23258
NCBI Accession:NP_001230183.1
UniProt Secondary Accession:Q6IQ26,Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1, B4DJ15, E9PS91
UniProt Related Accession:Q6IQ26
Molecular Weight:141
NCBI Full Name:DENN domain-containing protein 5A isoform 2
NCBI Synonym Full Names:DENN domain containing 5A
NCBI Official Symbol:DENND5A  
NCBI Official Synonym Symbols:EIEE49; RAB6IP1  
NCBI Protein Information:DENN domain-containing protein 5A
UniProt Protein Name:DENN domain-containing protein 5A
UniProt Synonym Protein Names:Rab6-interacting protein 1; Rab6IP1
UniProt Gene Name:DENND5A  
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