Name: Anti-delta Sarcoglycan Antibody (CAB9175)
Brand: Cell Biology Antibodies 17
SKU: CAB9175
Availability: OutOfStock

Antibody Name:	Anti-delta Sarcoglycan Antibody
Antibody SKU:	CAB9175
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human delta Sarcoglycan

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	A-549, RD, Mouse heart

Immunogen:	A synthesized peptide derived from human delta Sarcoglycan
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	6444
Uniprot:	Q92629
Cellular Location:
Calculated MW:	35kDa
Observed MW:	36KDa

Synonyms:

35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD

Background:

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

UniProt Protein Function:	SGCD: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F). LGMD2F is an autosomal recessive disorder. Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the sarcoglycan beta/delta/gamma/zeta family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Dystrophin complex; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q33-q34 Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; cytoplasm; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development Disease: Muscular Dystrophy, Limb-girdle, Type 2f; Cardiomyopathy, Dilated, 1l
NCBI Summary:	The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q92629
NCBI GenInfo Identifier:	212276471
NCBI Gene ID:	6444
NCBI Accession:	Q92629.2
UniProt Secondary Accession:	Q92629,Q53XA5, Q99644, A8K9S9,
UniProt Related Accession:	Q92629
Molecular Weight:	289
NCBI Full Name:	Delta-sarcoglycan
NCBI Synonym Full Names:	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
NCBI Official Symbol:	SGCD
NCBI Official Synonym Symbols:	SGD; DAGD; 35DAG; CMD1L; SGCDP; SG-delta
NCBI Protein Information:	delta-sarcoglycan; delta-SG; placental delta sarcoglycan; 35 kDa dystrophin-associated glycoprotein; dystrophin associated glycoprotein, delta sarcoglycan
UniProt Protein Name:	Delta-sarcoglycan
UniProt Synonym Protein Names:	35 kDa dystrophin-associated glycoprotein; 35DAG
Protein Family:	Delta-sarcoglycan
UniProt Gene Name:	SGCD
UniProt Entry Name:	SGCD_HUMAN