KO Validated Antibodies 1

Anti-Delta-Catenin/p120 Catenin Antibody (CAB18043)[KO Validated]

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SKU:
CAB18043
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Delta-Catenin/p120 Catenin Antibody [KO Validated]
Antibody SKU:CAB18043
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 573-832 of human Delta-Catenin/p120 Catenin (NP_001078938.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 573-832 of human Delta-Catenin/p120 Catenin (NP_001078938.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ILEA SAGA IQNL CAGR WTYG RYIR SALR QEKA LSAI ADLL TNEH ERVV KAAS GALR NLAV DARN KELI GKHA IPNL VKNL PGGQ QNSS WNFS EDTV ISIL NTIN EVIA ENLE AAKK LRET QGIE KLVL INKS GNRS EKEV RAAA LVLQ TIWG YKEL RKPL EKEG WKKS DFQV NLNN ASRS QSSH SYDD STLP LIDR NQKS DKKP DREE IQMS NMGS NTKS LDNN YSTP NERG DHNR TLDR SGDL GDME PLKG TTPL MQKI
Gene ID:1500
Uniprot:O60716
Cellular Location:Cell membrane, Cytoplasm, Nucleus
Calculated MW:65-72kDa/90-108kDa
Observed MW:100kDa
Anti-Delta-Catenin/p120 Catenin Antibody [KO Validated] (CAB18043)Western blot analysis of extracts from normal (control) and delta-Catenin/p120 Catenin knockout (KO) HeLa cells, using delta-Catenin/p120 Catenin antibody (CAB18043) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Synonyms:CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), CTNND1
Background:This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
UniProt Protein Function:CTNND1: an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Cell adhesion; Motility/polarity/chemotaxis; Adaptor/scaffold; G protein regulator, misc.; Actin-binding

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: growth cone; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; intercellular junction; midbody; zonula adherens; nucleus; cytosol

Molecular Function:protein binding; cadherin binding; protein kinase binding; receptor binding

Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; Wnt receptor signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; brain development; cell adhesion; vascular endothelial growth factor receptor signaling pathway

NCBI Summary:This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
UniProt Code:O60716
NCBI GenInfo Identifier:14916543
NCBI Gene ID:1500
NCBI Accession:O60716.1
UniProt Secondary Accession:O60716,O15088, O60713, O60714, O60715, O60935, Q6DHZ7 Q6RBX8, Q9UP71, Q9UP72, Q9UP73, A8K939,
UniProt Related Accession:O60716
Molecular Weight:65,641 Da
NCBI Full Name:Catenin delta-1
NCBI Synonym Full Names:catenin (cadherin-associated protein), delta 1
NCBI Official Symbol:CTNND1  
NCBI Official Synonym Symbols:CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)  
NCBI Protein Information:catenin delta-1; p120 catenin; cadherin-associated Src substrate
UniProt Protein Name:Catenin delta-1
UniProt Synonym Protein Names:Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas)
Protein Family:Catenin
UniProt Gene Name:CTNND1  
UniProt Entry Name:CTND1_HUMAN
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