Cell Biology Antibodies 7
Anti-Delta-Catenin/p120 Catenin Antibody (CAB1641)
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- SKU:
- CAB1641
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Delta-Catenin/p120 Catenin Antibody |
| Antibody SKU: | CAB1641 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 573-832 of human Delta-Catenin/p120 Catenin (NP_001078938.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, U-251MG, 293T, A-549, 22Rv1, HT-29, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 573-832 of human Delta-Catenin/p120 Catenin (NP_001078938.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ILEA SAGA IQNL CAGR WTYG RYIR SALR QEKA LSAI ADLL TNEH ERVV KAAS GALR NLAV DARN KELI GKHA IPNL VKNL PGGQ QNSS WNFS EDTV ISIL NTIN EVIA ENLE AAKK LRET QGIE KLVL INKS GNRS EKEV RAAA LVLQ TIWG YKEL RKPL EKEG WKKS DFQV NLNN ASRS QSSH SYDD STLP LIDR NQKS DKKP DREE IQMS NMGS NTKS LDNN YSTP NERG DHNR TLDR SGDL GDME PLKG TTPL MQKI |
| Gene ID: | 1500 |
| Uniprot: | O60716 |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus |
| Calculated MW: | 65-72kDa/90-108kDa |
| Observed MW: | 108kDa |
| Synonyms: | CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), CTNND1 |
| Background: | This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. |
| UniProt Protein Function: | CTNND1: an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Adaptor/scaffold; G protein regulator, misc.; Actin-binding Chromosomal Location of Human Ortholog: 11q11 Cellular Component: growth cone; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; intercellular junction; midbody; zonula adherens; nucleus; cytosol Molecular Function:protein binding; cadherin binding; protein kinase binding; receptor binding Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; Wnt receptor signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; brain development; cell adhesion; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O60716 |
| NCBI GenInfo Identifier: | 14916543 |
| NCBI Gene ID: | 1500 |
| NCBI Accession: | O60716.1 |
| UniProt Secondary Accession: | O60716,O15088, O60713, O60714, O60715, O60935, Q6DHZ7 Q6RBX8, Q9UP71, Q9UP72, Q9UP73, A8K939, |
| UniProt Related Accession: | O60716 |
| Molecular Weight: | 65,641 Da |
| NCBI Full Name: | Catenin delta-1 |
| NCBI Synonym Full Names: | catenin (cadherin-associated protein), delta 1 |
| NCBI Official Symbol: | CTNND1 |
| NCBI Official Synonym Symbols: | CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN) |
| NCBI Protein Information: | catenin delta-1; p120 catenin; cadherin-associated Src substrate |
| UniProt Protein Name: | Catenin delta-1 |
| UniProt Synonym Protein Names: | Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas) |
| Protein Family: | Catenin |
| UniProt Gene Name: | CTNND1 |
| UniProt Entry Name: | CTND1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using delta-Catenin/p120 Catenin antibody (CAB1641) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of U2OS cells using delta-Catenin/p120 Catenin antibody (CAB1641). Blue: DAPI for nuclear staining. |
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