Anti-DEK Antibody (CAB0315)
- SKU:
- CAB0315
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- D6S231E
- Research Area:
- Cell Biology
Description
| Product Name: | DEK Rabbit mAb |
| Product Code: | CAB0315 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | D6S231E |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human DEK |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, HCT116, K-562 |
| Immunogen: | A synthesized peptide derived from human DEK |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7913 |
| Uniprot: | P35659 |
| Calculated MW: | 43kDa |
| Observed MW: | 50KDa |
| UniProt Protein Function: | DEK: a ubiquitous protein with a SAP domain, which is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemias (AML). |
| UniProt Protein Details: | Protein type:Histone-binding; Oncoprotein; DNA-binding; DNA replication; RNA splicing Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: contractile fiber; nucleoplasm; nucleus Molecular Function:DNA binding; histone binding Biological Process: chromatin modification; positive regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription from RNA polymerase II promoter; viral genome replication |
| NCBI Summary: | This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P35659 |
| NCBI GenInfo Identifier: | 544150 |
| NCBI Gene ID: | 7913 |
| NCBI Accession: | P35659.1 |
| UniProt Related Accession: | P35659 |
| Molecular Weight: | |
| NCBI Full Name: | Protein DEK |
| NCBI Synonym Full Names: | DEK proto-oncogene |
| NCBI Official Symbol: | DEK |
| NCBI Official Synonym Symbols: | D6S231E |
| NCBI Protein Information: | protein DEK |
| UniProt Protein Name: | Protein DEK |
| Protein Family: | Protein |
| UniProt Gene Name: | DEK |
| UniProt Entry Name: | DEK_HUMAN |
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