Metabolism Antibodies 1
Anti-DEGS1 Antibody (CAB12648)
(No reviews yet)
Write a Review
- SKU:
- CAB12648
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-DEGS1 Antibody |
| Antibody SKU: | CAB12648 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-323 of human DEGS1 (NP_003667.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:3000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, A-549, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-323 of human DEGS1 (NP_003667.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YMFL KGHE TYSY YGPL NLLT FNVG YHNE HHDF PNIP GKSL PLVR KIAA EYYD NLPH YNSW IKVL YDFV MDDT ISPY SRMK RHQK GEMV LE |
| Gene ID: | 8560 |
| Uniprot: | O15121 |
| Cellular Location: | Endoplasmic reticulum membrane, Lipid-anchor, Membrane, Mitochondrion, Multi-pass membrane protein |
| Calculated MW: | 37kDa |
| Observed MW: | 38kDa |
| Synonyms: | DEGS1, DEGS, DEGS-1, DES1, Des-1, FADS7, MIG15, MLD |
| Background: | This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. |
| UniProt Protein Function: | DEGS1: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desaturase family. DEGS subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Oxidoreductase; EC 1.14.-.-; Lipid Metabolism - sphingolipid Chromosomal Location of Human Ortholog: 1q42.11 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane Molecular Function:electron carrier activity; sphingolipid delta-4 desaturase activity Biological Process: sphingolipid biosynthetic process; unsaturated fatty acid biosynthetic process |
| NCBI Summary: | This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010] |
| UniProt Code: | O15121 |
| NCBI GenInfo Identifier: | 74739483 |
| NCBI Gene ID: | 8560 |
| NCBI Accession: | O15121.1 |
| UniProt Related Accession: | O15121 |
| Molecular Weight: | 37,866 Da |
| NCBI Full Name: | Sphingolipid delta(4)-desaturase DES1 |
| NCBI Synonym Full Names: | delta 4-desaturase, sphingolipid 1 |
| NCBI Official Symbol: | DEGS1 |
| NCBI Official Synonym Symbols: | MLD; DEGS; DES1; Des-1; FADS7; MIG15; DEGS-1 |
| NCBI Protein Information: | sphingolipid delta(4)-desaturase DES1 |
| UniProt Protein Name: | Sphingolipid delta(4)-desaturase DES1 |
| UniProt Synonym Protein Names: | Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Membrane lipid desaturase |
| UniProt Gene Name: | DEGS1 |
| UniProt Entry Name: | DEGS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DEGS1 antibody (CAB12648) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human DEGS1 (Sphingolipid delta (4)-desaturase DES1) ELISA Kit (HUFI05315)
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीकी
Human anti-ASGPR antibody(anti asialoglyco protein receptor antibody)ELISA Kit
OverviewProduct Name:Human anti-ASGPR antibody(anti asialoglyco protein receptor antibody)ELISA KitProduct Code:AEFI00360Size:96TAlias:a
