Cell Death Antibodies 2

Anti-DEDD Antibody (CAB5806)

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SKU:
CAB5806
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-DEDD Antibody
Antibody SKU:CAB5806
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human DEDD (NP_001034801.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human DEDD (NP_001034801.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGL KRRA SQVW PEEH GEQE HGLY SLHR MFDI VGTH LTHR DVRV LSFL FVDV IDDH ERGL IRNG RDFL LALE RQGR CDES NFRQ VLQL LRII TRHD LLPY VTLK RRRA VCPD LVDK YLEE TSIR YVTP RALS DPEP RPPQ PSKT VPPH YPVV CCPT SGPQ MCSK RPAR GRAT LGSQ RKRR KSVT PDPK EKQT CDIR LRVR AEYC QHET ALQG NVFS NKQD PLER QFER FNQA NTIL KSRD LGSI ICDI KFSE LTYL DAFW RDYI NGSL LEAL KGVF ITDS LKQA VGHE AIKL LVNV DEED YELG RQKL LRNL MLQA LP
Gene ID:9191
Uniprot:O75618
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:36kDa/40kDa
Observed MW:Refer to Figures
Synonyms:DEDD, CASP8IP1, DEDD1, DEFT, FLDED1, KE05
Background:This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
UniProt Protein Function:DEDD: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytoplasm; nucleolus

Molecular Function:DNA binding; protein binding

NCBI Summary:This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O75618
NCBI GenInfo Identifier:21759089
NCBI Gene ID:9191
NCBI Accession:O75618.1
UniProt Secondary Accession:O75618,O60737, D3DVF5,
UniProt Related Accession:O75618
Molecular Weight:40,418 Da
NCBI Full Name:Death effector domain-containing protein
NCBI Synonym Full Names:death effector domain containing
NCBI Official Symbol:DEDD  
NCBI Official Synonym Symbols:DEFT; KE05; DEDD1; FLDED1; CASP8IP1  
NCBI Protein Information:death effector domain-containing protein
UniProt Protein Name:Death effector domain-containing protein
UniProt Synonym Protein Names:DEDPro1; Death effector domain-containing testicular molecule; FLDED-1
Protein Family:Death effector domain-containing protein
UniProt Gene Name:DEDD  
UniProt Entry Name:DEDD_HUMAN
Anti-DEDD Antibody (CAB5806)Immunohistochemistry of paraffin-embedded rat lung using DEDD antibody (CAB5806) at dilution of 1:100 (40x lens).
Anti-DEDD Antibody (CAB5806)Immunohistochemistry of paraffin-embedded human esophagus using DEDD antibody (CAB5806) at dilution of 1:100 (40x lens).
Anti-DEDD Antibody (CAB5806)Immunohistochemistry of paraffin-embedded mouse kidney using DEDD antibody (CAB5806) at dilution of 1:100 (40x lens).
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