Metabolism Antibodies 2
Anti-DDC Antibody (CAB3828)
- SKU:
- CAB3828
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-DDC Antibody |
| Antibody SKU: | CAB3828 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DDC (NP_000781.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, SW620, PC-12, Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DDC (NP_000781.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNAS EFRR RGKE MVDY VANY MEGI EGRQ VYPD VEPG YLRP LIPA AAPQ EPDT FEDI INDV EKII MPGV THWH SPYF FAYF PTAS SYPA MLAD MLCG AIGC |
| Gene ID: | 1644 |
| Uniprot: | P20711 |
| Cellular Location: | |
| Calculated MW: | 37kDa/44kDa/45kDa/53kDa |
| Observed MW: | 54-56kDa |
| Synonyms: | DDC, AADC |
| Background: | The encoded protein catalyzes the decarboxylation of L-3, 4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
| UniProt Protein Function: | DDC: Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; EC 4.1.1.28; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Nuclear receptor co-regulator; Amino Acid Metabolism - phenylalanine; Lyase Chromosomal Location of Human Ortholog: 7p12.2 Cellular Component: synaptic vesicle; cell soma; axon; cytosol Molecular Function:aromatic-L-amino-acid decarboxylase activity; protein domain specific binding; amino acid binding; protein binding; enzyme binding; pyridoxal phosphate binding Biological Process: circadian rhythm; amino acid metabolic process; catecholamine biosynthetic process; indolalkylamine biosynthetic process; multicellular organismal aging; isoquinoline alkaloid metabolic process; dopamine biosynthetic process; serotonin biosynthetic process; phytoalexin metabolic process; synaptic vesicle amine transport; response to pyrethroid Disease: Aromatic L-amino Acid Decarboxylase Deficiency |
| NCBI Summary: | The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011] |
| UniProt Code: | P20711 |
| NCBI GenInfo Identifier: | 311033369 |
| NCBI Gene ID: | 1644 |
| NCBI Accession: | P20711.2 |
| UniProt Secondary Accession: | P20711,O88533, P14173, |
| UniProt Related Accession: | P20711 |
| Molecular Weight: | 480 |
| NCBI Full Name: | Aromatic-L-amino-acid decarboxylase |
| NCBI Synonym Full Names: | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
| NCBI Official Symbol: | DDC |
| NCBI Official Synonym Symbols: | AADC |
| NCBI Protein Information: | aromatic-L-amino-acid decarboxylase |
| UniProt Protein Name: | Aromatic-L-amino-acid decarboxylase |
| UniProt Synonym Protein Names: | DOPA decarboxylase; DDC |
| Protein Family: | Aromatic-L-amino-acid decarboxylase |
| UniProt Gene Name: | DDC |
| UniProt Entry Name: | DDC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DDC antibody (CAB3828) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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