Metabolism Antibodies 2
Anti-DCXR Antibody (CAB4721)
- SKU:
- CAB4721
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DCXR
- Synonyms:
- DCR
- Synonyms:
- HCR2
- Synonyms:
- HCRII
- Synonyms:
- KIDCR
- Synonyms:
- P34H
- Synonyms:
- PNTSU
- Synonyms:
- SDR20C1
- Synonyms:
- XR
- Research Area:
- Metabolism
Description
| Product Name: | DCXR Rabbit pAb |
| Product Code: | CAB4721 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | DCXR, DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human DCXR (NP_057370.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, MCF7, NCI-H460, Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human DCXR (NP_057370.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MELF LAGR RVLV TGAG KGIG RGTV QALH ATGA RVVA VSRT QADL DSLV RECP GIEP VCVD LGDW EATE RALG SVGP VDLL VNNA AVAL LQPF LEVT KEAF DRSF EVNL RAVI QVSQ IVAR GLIA RGVP GAIV NVSS QCSQ RAVT NHSV YCST KGAL DMLT KVMA LELG PHKI RVNA VNPT VVMT SMGQ ATWS DPHK AKTM LNRI PLGK FAEV EHVV NAIL FLLS DRSG MTTG STLP VEGG FWAC |
| Gene ID: | 51181 |
| Uniprot: | Q7Z4W1 |
| Cellular Location: | Membrane, Peripheral membrane protein |
| Calculated MW: | 25kDa |
| Observed MW: | 31kDa |
| UniProt Protein Function: | DCXR: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 1.1.1.10 Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: microvillus; membrane; cytoplasmic microtubule; nucleus; brush border Molecular Function:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; L-xylulose reductase activity Biological Process: glucose metabolic process; xylulose metabolic process; D-xylose metabolic process; NADP metabolic process; protein homotetramerization Disease: Pentosuria |
| NCBI Summary: | The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010] |
| UniProt Code: | Q7Z4W1 |
| NCBI GenInfo Identifier: | 50400451 |
| NCBI Gene ID: | 51181 |
| NCBI Accession: | Q7Z4W1.2 |
| UniProt Related Accession: | Q7Z4W1 |
| Molecular Weight: | |
| NCBI Full Name: | L-xylulose reductase |
| NCBI Synonym Full Names: | dicarbonyl and L-xylulose reductase |
| NCBI Official Symbol: | DCXR |
| NCBI Official Synonym Symbols: | XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1 |
| NCBI Protein Information: | L-xylulose reductase |
| UniProt Protein Name: | L-xylulose reductase |
| UniProt Synonym Protein Names: | Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Sperm surface protein P34H |
| UniProt Gene Name: | DCXR |
| UniProt Entry Name: | DCXR_HUMAN |
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