Signal Transduction Antibodies 1
Anti-DCUN1D1 Antibody (CAB14587)
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- SKU:
- CAB14587
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-DCUN1D1 Antibody |
| Antibody SKU: | CAB14587 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-70 of human DCUN1D1 (NP_065691.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Mouse testis, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-70 of human DCUN1D1 (NP_065691.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FMIF TQSS EKTA VSCL SQND WKLD VATD NFFQ NPEL YIRE SVKG SLDR KKLE QLYN |
| Gene ID: | 54165 |
| Uniprot: | Q96GG9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 30kDa |
| Observed MW: | 30kDa |
| Synonyms: | DCUN1D1, DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3 |
| Background: |
| UniProt Protein Function: | DCUN1D1: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. |
| UniProt Protein Details: | Protein type:Oncoprotein; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3q26.3 Cellular Component: nucleus; ubiquitin ligase complex Molecular Function:protein binding; small conjugating protein binding; ubiquitin conjugating enzyme binding Biological Process: positive regulation of ubiquitin-protein ligase activity; protein neddylation |
| UniProt Code: | Q96GG9 |
| NCBI GenInfo Identifier: | 809281410 |
| NCBI Gene ID: | 54165 |
| NCBI Accession: | NP_001295030.1 |
| UniProt Secondary Accession: | Q96GG9,Q7L3G9, Q8TEX7, Q9H6M1, Q9HCT3, B2RB37, |
| UniProt Related Accession: | Q96GG9 |
| Molecular Weight: | 30,124 Da |
| NCBI Full Name: | DCN1-like protein 1 isoform 2 |
| NCBI Synonym Full Names: | defective in cullin neddylation 1 domain containing 1 |
| NCBI Official Symbol: | DCUN1D1 |
| NCBI Official Synonym Symbols: | RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1 |
| NCBI Protein Information: | DCN1-like protein 1 |
| UniProt Protein Name: | DCN1-like protein 1 |
| UniProt Synonym Protein Names: | DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene |
| Protein Family: | DCN1-like protein |
| UniProt Gene Name: | DCUN1D1 |
| UniProt Entry Name: | DCNL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DCUN1D1 antibody (CAB14587) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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