Epigenetics & Nuclear Signaling Antibodies 2
Anti-DCTD Antibody (CAB5889)
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- SKU:
- CAB5889
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-DCTD Antibody |
| Antibody SKU: | CAB5889 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human DCTD (NP_001912.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, Mouse heart, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human DCTD (NP_001912.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSEV SCKK RDDY LEWP EYFM AVAF LSAQ RSKD PNSQ VGAC IVNS ENKI VGIG YNGM PNGC SDDV LPWR RTAE NKLD TKYP YVCH AELN AIMN KNST DVKG CSMY VALF PCNE CAKL IIQA GIKE VIFM SDKY HDSD EATA ARLL FNMA GVTF RKFI PKCS KIVI DFDS INSR PSQK LQ |
| Gene ID: | 1635 |
| Uniprot: | P32321 |
| Cellular Location: | |
| Calculated MW: | 20kDa/21kDa |
| Observed MW: | 23kDa |
| Synonyms: | DCTD |
| Background: | The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | DCTD: catalyzes the deamination of dCMP to dUMP, thus providing the nucleotide substrate for thymidylate synthase. Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; EC 3.5.4.12; Hydrolase Chromosomal Location of Human Ortholog: 4q35.1 Cellular Component: cytosol Molecular Function:zinc ion binding; dCMP deaminase activity Biological Process: pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleotide biosynthetic process; pyrimidine nucleotide metabolic process; pyrimidine nucleoside biosynthetic process |
| NCBI Summary: | The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32321 |
| NCBI GenInfo Identifier: | 23503055 |
| NCBI Gene ID: | 1635 |
| NCBI Accession: | P32321.2 |
| UniProt Secondary Accession: | P32321,Q5M7Z8, Q9BVD8, B2R836, D3DP49, D3DP50, |
| UniProt Related Accession: | P32321 |
| Molecular Weight: | 178 |
| NCBI Full Name: | Deoxycytidylate deaminase |
| NCBI Synonym Full Names: | dCMP deaminase |
| NCBI Official Symbol: | DCTD |
| NCBI Protein Information: | deoxycytidylate deaminase |
| UniProt Protein Name: | Deoxycytidylate deaminase |
| UniProt Synonym Protein Names: | dCMP deaminase |
| Protein Family: | Deoxycytidylate deaminase |
| UniProt Gene Name: | DCTD |
| UniProt Entry Name: | DCTD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DCTD antibody (CAB5889) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using DCTD antibody (CAB5889) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using DCTD antibody (CAB5889) at dilution of 1:200 (40x lens). |
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