Metabolism Antibodies 2
Anti-DCT Antibody (CAB6287)
- SKU:
- CAB6287
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-DCT Antibody |
| Antibody SKU: | CAB6287 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human DCT (NP_001913.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-431, LO2, MCF7, COS-7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human DCT (NP_001913.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NVCG SQQG RGQC TEVR ADTR PWSG PYIL RNQD DREL WPRK FFHR TCKC TGNF AGYN CGDC KFGW TGPN CERK KPPV IRQN IHSL SPQE REQF LGAL DLAK KRVH PDYV ITTQ HWLG LLGP NGTQ PQFA NCSV YDFF VWLH YYSV RDTL LGPG RPYR AIDF SHQG PAFV TWHR YHLL CLER DLQR LIGN ESFA LPYW NFAT GRNE CDVC TDQL FGAA RPDD PTLI SRNS RFSS WETV CDSL DDYN HLVT LCNG TYEG LLRR NQMG RNSM KLPT LKDI RDCL SLQK FDNP PFFQ NSTF SFRN A |
| Gene ID: | 1638 |
| Uniprot: | P40126 |
| Cellular Location: | Melanosome membrane, Single-pass type I membrane protein |
| Calculated MW: | 59kDa/62kDa |
| Observed MW: | 59kDa |
| Synonyms: | DCT, TRP-2, TYRP2 |
| Background: |
| UniProt Protein Function: | DCT: Involved in regulating eumelanin and phaeomelanin levels. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 5.3.3.12; Cell development/differentiation; Membrane protein, integral; Isomerase; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: 13q32 Cellular Component: cytosol; melanosome; melanosome membrane Molecular Function:copper ion binding; dopachrome isomerase activity; oxidoreductase activity Biological Process: epidermis development; melanin biosynthetic process; melanin biosynthetic process from tyrosine |
| UniProt Code: | P40126 |
| NCBI GenInfo Identifier: | 731026 |
| NCBI Gene ID: | 1638 |
| NCBI Accession: | P40126.1 |
| UniProt Secondary Accession: | P40126,Q09GT4, |
| UniProt Related Accession: | P40126 |
| Molecular Weight: | 62,929 Da |
| NCBI Full Name: | L-dopachrome tautomerase |
| NCBI Synonym Full Names: | dopachrome tautomerase |
| NCBI Official Symbol: | DCT |
| NCBI Official Synonym Symbols: | TRP-2; TYRP2 |
| NCBI Protein Information: | L-dopachrome tautomerase |
| UniProt Protein Name: | L-dopachrome tautomerase |
| UniProt Synonym Protein Names: | L-dopachrome Delta-isomerase; Tyrosinase-related protein 2; TRP-2; TRP2 |
| Protein Family: | dCTP deaminase |
| UniProt Gene Name: | DCT |
| UniProt Entry Name: | TYRP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DCT antibody (CAB6287) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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