Epigenetics & Nuclear Signaling Antibodies 5

Anti-DCP1A Antibody (CAB6824)

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SKU:
CAB6824
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-DCP1A Antibody
Antibody SKU:CAB6824
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human DCP1A
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, 293T, HepG2, SH-SY5Y
Immunogen:A synthesized peptide derived from human DCP1A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:55802
Uniprot:Q9NPI6
Cellular Location:
Calculated MW:75kDa
Observed MW:73KDa
Synonyms:HSA275986, Nbla00360, SMAD4IP1, SMIF
Background:Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Protein Function:DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling.
UniProt Protein Details:

Protein type:RNA processing; Transcription, coactivator/corepressor; EC 3.-.-.-; Hydrolase

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cytosol; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function:enzyme activator activity; enzyme regulator activity; hydrolase activity; identical protein binding; mRNA binding; protein binding

Biological Process: deadenylation-dependent decapping; deadenylation-independent decapping; gene expression; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity; regulation of mRNA stability

NCBI Summary:Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Code:Q9NPI6
NCBI GenInfo Identifier:296434475
NCBI Gene ID:55802
NCBI Accession:Q9NPI6.2
UniProt Secondary Accession:Q9NPI6,B4DHN9, U3KQM8,
UniProt Related Accession:Q9NPI6
Molecular Weight:59,361 Da
NCBI Full Name:mRNA-decapping enzyme 1A
NCBI Synonym Full Names:decapping mRNA 1A
NCBI Official Symbol:DCP1A  
NCBI Official Synonym Symbols:SMIF; SMAD4IP1; HSA275986; Nbla00360  
NCBI Protein Information:mRNA-decapping enzyme 1A
UniProt Protein Name:mRNA-decapping enzyme 1A
UniProt Synonym Protein Names:Smad4-interacting transcriptional co-activator; Transcription factor SMIF
Protein Family:mRNA-decapping enzyme
UniProt Gene Name:DCP1A  
UniProt Entry Name:DCP1A_HUMAN
Anti-DCP1A Antibody (CAB6824)Western blot - DCP1A Rabbit mAb (CAB6824)
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