Cell Cycle Antibodies 1

Anti-DCLRE1A Antibody (CAB14312)

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SKU:
CAB14312
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-DCLRE1A Antibody
Antibody SKU:CAB14312
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1A (NP_001258745.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG, LO2, 293T, HeLa, A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1A (NP_001258745.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLED ISEE DIWE YKSK RKPK RVDP NNGS KNIL KSVE KATD GKYQ SKRS RNRK RAAE AKEV KDHE VPLG NAGC QTSV ASSQ NSSC GDGI QQTQ DKET TPGK LCRT QKSQ HVSP KIRP VYDG YCPN CQMP FSSL IGQT PRWH VFEC LDSP PRSE TECP DGLL CTST IPFH YKRY THFL LAQS RAGD HPFS SPSP ASGG SFSE TKSG VLCS LEER WSSY QNQT DNSV SNDP LLMT QYFK KSPS LTEA SEKI STHI QTSQ QALQ FTDF VEND KLVG VALR LANN SEHI NLPL PEND FSDC EISY
Gene ID:9937
Uniprot:Q6PJP8
Cellular Location:Nucleus
Calculated MW:116kDa
Observed MW:116kDa
Synonyms:DCLRE1A, PSO2, SNM1, SNM1A
Background:This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:DCLRE1A: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: nucleolus; nucleus

Biological Process: mitosis; cell division; nucleotide-excision repair

NCBI Summary:This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
UniProt Code:Q6PJP8
NCBI GenInfo Identifier:425871110
NCBI Gene ID:9937
NCBI Accession:NP_001258745.1
UniProt Secondary Accession:Q6PJP8,Q14701, Q6P5Y3, Q6PKL4, D3DRC1,
UniProt Related Accession:Q6PJP8
Molecular Weight:116,400 Da
NCBI Full Name:DNA cross-link repair 1A protein
NCBI Synonym Full Names:DNA cross-link repair 1A
NCBI Official Symbol:DCLRE1A  
NCBI Official Synonym Symbols:PSO2; SNM1; SNM1A  
NCBI Protein Information:DNA cross-link repair 1A protein; SNM1 homolog A; DNA-crosslink repair gene SNM1
UniProt Protein Name:DNA cross-link repair 1A protein
UniProt Synonym Protein Names:SNM1 homolog A; hSNM1; hSNM1A
UniProt Gene Name:DCLRE1A  
UniProt Entry Name:DCR1A_HUMAN
Anti-DCLRE1A Antibody (CAB14312)Western blot analysis of extracts of various cell lines, using DCLRE1A antibody (CAB14312) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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