| Background: | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. |
| UniProt Protein Function: | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| NCBI Summary: | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010] |
| UniProt Code: | O15075 |
| NCBI GenInfo Identifier: | 6225242 |
| NCBI Gene ID: | 9201 |
| NCBI Accession: | O15075.2 |
| UniProt Secondary Accession: | O15075,Q5VZY8, Q5VZZ0, Q5VZZ1, B7Z3E9, |
| UniProt Related Accession: | O15075 |
| Molecular Weight: | 47,681 Da |
| NCBI Full Name: | Serine/threonine-protein kinase DCLK1 |
| NCBI Synonym Full Names: | doublecortin like kinase 1 |
| NCBI Official Symbol: | DCLK1 |
| NCBI Official Synonym Symbols: | CL1; DCLK; CLICK1; DCDC3A; DCAMKL1 |
| NCBI Protein Information: | serine/threonine-protein kinase DCLK1 |
| UniProt Protein Name: | Serine/threonine-protein kinase DCLK1 |
| UniProt Synonym Protein Names: | Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | DCLK1 |
| UniProt Entry Name: | DCLK1_HUMAN |
