Cell Biology Antibodies 13

Anti-DCDC2 Antibody (CAB17704)

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SKU:
CAB17704
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DCDC2 Antibody
Antibody SKU:CAB17704
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DCDC2 (NP_001182539).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HeLa, Mouse pancreas, Rat brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DCDC2 (NP_001182539).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGS SARS SHLS QPVV KSVL VYRN GDPF YAGR RVVI HEKK VSSF EVFL KEVT GGVQ APFG AVRN IYTP RTGH RIRK LDQI QSGG NYVA GGQE AFKK LNYL DIGE IKKR PMEV VNTE VKPV IHSR INVS ARFR KPLQ EPCT IFLI ANGD LINP ASRL LIPR KTLN QWDH VLQM VTEK ITLR SGAV HRLY TLEG KLVE SGAE LENG QFYV AVGR DKFK KLPY SELL FDKS TMRR PFGQ KASS LPPI VGSR KS
Gene ID:51473
Uniprot:Q9UHG0
Cellular Location:
Calculated MW:
Observed MW:53kDa
Anti-DCDC2 Antibody (CAB17704)Western blot - DCDC2 Polyclonal Antibody (CAB17704)
Synonyms:DCDC2A, DFNB66, NPHP19, RU2, RU2S, DCDC2
Background:This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Protein Function:DCDC2: May be involved in neuronal migration during development of the cerebral neocortex. Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2); also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: axoneme; cytoplasm; nucleus

Molecular Function:protein binding

Biological Process: cellular defense response; neuron migration; positive regulation of smoothened signaling pathway; regulation of Wnt receptor signaling pathway; sensory perception of sound

Disease: Deafness, Autosomal Recessive 66; Nephronophthisis 19

NCBI Summary:This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Code:Q9UHG0
NCBI GenInfo Identifier:147744557
NCBI Gene ID:51473
NCBI Accession:Q9UHG0.2
UniProt Secondary Accession:Q9UHG0,Q5VTR8, Q5VTR9, Q86W35, Q9UFD1, Q9UHG1, Q9ULR6
UniProt Related Accession:Q9UHG0
Molecular Weight:25,582 Da
NCBI Full Name:Doublecortin domain-containing protein 2
NCBI Synonym Full Names:doublecortin domain containing 2
NCBI Official Symbol:DCDC2  
NCBI Official Synonym Symbols:RU2; RU2S; DCDC2A; DFNB66; NPHP19  
NCBI Protein Information:doublecortin domain-containing protein 2
UniProt Protein Name:Doublecortin domain-containing protein 2
UniProt Synonym Protein Names:Protein RU2S
Protein Family:Doublecortin domain-containing protein
UniProt Gene Name:DCDC2  
UniProt Entry Name:DCDC2_HUMAN
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