Metabolism Antibodies 1
Anti-DBH Antibody (CAB13971)
- SKU:
- CAB13971
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-DBH Antibody |
| Antibody SKU: | CAB13971 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GYCT DKCT QLAL PPSG IHIF ASQL HTHL TGRK VVTV LVRD GREW EIVN QDNH YSPH FQEI RMLK KVVS VHPG DVLI TSCT YNTE DREL ATVG GFGI LEEM CVNY VHYY PQTQ LELC KSAV DAGF LQKY FHLI NRFN NEDV CTCP QASV SQQF TSVP WNSF NRDV LKAL YSFA PISM HCNK SSAV RFQG EWNL QPLP KVIS TLEE PTPQ CPTS QGRS PAGP TVVS IGGG KG |
| Gene ID: | 1621 |
| Uniprot: | P09172 |
| Cellular Location: | Cytoplasmic vesicle, Single-pass type II membrane protein, chromaffin granule lumen, chromaffin granule membrane, secretory vesicle, secretory vesicle lumen, secretory vesicle membrane |
| Calculated MW: | 69kDa |
| Observed MW: | Refer to figures |
| Synonyms: | DBH, DBM |
| Background: | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. |
| UniProt Protein Function: | DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; EC 1.14.17.1; Oxidoreductase; Apoptosis; Amino Acid Metabolism - tyrosine; Cell cycle regulation Chromosomal Location of Human Ortholog: 9q34 Cellular Component: membrane; cytoplasm; integral to membrane; extracellular region Molecular Function:copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration Disease: Dopamine Beta-hydroxylase Deficiency, Congenital |
| NCBI Summary: | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017] |
| UniProt Code: | P09172 |
| NCBI GenInfo Identifier: | 158517849 |
| NCBI Gene ID: | 1621 |
| NCBI Accession: | P09172.3 |
| UniProt Related Accession: | P09172 |
| Molecular Weight: | |
| NCBI Full Name: | Dopamine beta-hydroxylase |
| NCBI Synonym Full Names: | dopamine beta-hydroxylase |
| NCBI Official Symbol: | DBH |
| NCBI Official Synonym Symbols: | DBM; ORTHYP1 |
| NCBI Protein Information: | dopamine beta-hydroxylase |
| UniProt Protein Name: | Dopamine beta-hydroxylase |
| UniProt Synonym Protein Names: | Dopamine beta-monooxygenaseSoluble dopamine beta-hydroxylase |
| Protein Family: | Dopamine beta-hydroxylase |
| UniProt Gene Name: | DBH |
| UniProt Entry Name: | DOPO_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver using DBH antibody (CAB13971) at dilution of 1:200 (40x lens). |
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