Cell Biology Antibodies 4

Anti-DAZAP2 Antibody (CAB14266)

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SKU:
CAB14266
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-DAZAP2 Antibody
Antibody SKU:CAB14266
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DAZAP2 (NP_055579.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain, Mouse heart, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DAZAP2 (NP_055579.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNSK GQYP TQPT YPVQ PPGN PVYP QTLH LPQA PPYT DAPP AYSE LYRP SFVH PGAA TVPT MSAA FPGA SLYL PMAQ SVAV GPLG STIP MAYY PVGP IYPP GSTV LVEG GYDA GARF GAGA TAGN IPPP PPGC PPNA AQLA VMQG ANVL VTQR KGNF FMGG SDGG YTIW
Gene ID:9802
Uniprot:Q15038
Cellular Location:Cytoplasm, Nucleus
Calculated MW:9kDa/13kDa/15kDa/16kDa/17kDa/22kDa
Observed MW:17kDa
Synonyms:DAZAP2, PRTB
Background:This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:DAZAP2: 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 12q12

Molecular Function:protein binding; WW domain binding

NCBI Summary:This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Code:Q15038
NCBI GenInfo Identifier:44887865
NCBI Gene ID:9802
NCBI Accession:Q15038.1
UniProt Secondary Accession:Q15038,A8K254, B4DDT5, B4E1G3, C9JA96, C9JP84, E9PB45 F8VU62,
UniProt Related Accession:Q15038
Molecular Weight:22,823 Da
NCBI Full Name:DAZ-associated protein 2
NCBI Synonym Full Names:DAZ associated protein 2
NCBI Official Symbol:DAZAP2  
NCBI Official Synonym Symbols:PRTB  
NCBI Protein Information:DAZ-associated protein 2
UniProt Protein Name:DAZ-associated protein 2
UniProt Synonym Protein Names:Deleted in azoospermia-associated protein 2
Protein Family:DAZ-associated protein
UniProt Gene Name:DAZAP2  
UniProt Entry Name:DAZP2_HUMAN
Anti-DAZAP2 Antibody (CAB14266)Western blot analysis of extracts of various cell lines, using DAZAP2 Rabbit pAb (CAB14266) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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