Anti-Daxx Antibody (CAB19661)
- SKU:
- CAB19661
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BING2
- Synonyms:
- DAP6
- Synonyms:
- EAP1
Description
| Product Name: | Daxx Rabbit mAb |
| Product Code: | CAB19661 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BING2, DAP6, EAP1 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Daxx |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human Daxx |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1616 |
| Uniprot: | Q9UER7 |
| Calculated MW: | 81kDa |
| Observed MW: | 110KDa |
| UniProt Protein Function: | DAXX: a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF-betaR2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF-betaR2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Nucleolus; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Apoptosis Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: chromosome, pericentric region; cytoplasm; cytosol; nucleoplasm; nucleus; PML body Molecular Function:androgen receptor binding; enzyme binding; heat shock protein binding; histone binding; p53 binding; protein binding; protein kinase activator activity; protein kinase binding; protein N-terminus binding; receptor signaling protein activity; transcription corepressor activity; ubiquitin protein ligase binding Biological Process: activation of JNK activity; androgen receptor signaling pathway; apoptosis; chromatin remodeling; induction of apoptosis via death domain receptors; negative regulation of transcription, DNA-dependent; nucleosome assembly; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; regulation of protein ubiquitination; regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9UER7 |
| NCBI GenInfo Identifier: | 24636785 |
| NCBI Gene ID: | 1616 |
| NCBI Accession: | Q9UER7.2 |
| UniProt Secondary Accession: | Q9UER7,O14747, O15141, O15208, Q5STK9, Q9BWI3, B4E1I3 F5ANJ6, F5ANJ7, F5H082, |
| UniProt Related Accession: | Q9UER7 |
| Molecular Weight: | 75,563 Da |
| NCBI Full Name: | Death domain-associated protein 6 |
| NCBI Synonym Full Names: | death domain associated protein |
| NCBI Official Symbol: | DAXX |
| NCBI Official Synonym Symbols: | DAP6; EAP1; BING2 |
| NCBI Protein Information: | death domain-associated protein 6 |
| UniProt Protein Name: | Death domain-associated protein 6 |
| UniProt Synonym Protein Names: | Daxx; hDaxx; ETS1-associated protein 1; EAP1; Fas death domain-associated protein |
| Protein Family: | Death domain-associated protein |
| UniProt Gene Name: | DAXX |
| UniProt Entry Name: | DAXX_HUMAN |
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