Anti-DARPP32 Antibody (CAB4027)

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SKU:
CAB4027
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DARPP-32
Synonyms:
DARPP32
Research Area:
Cell Biology

Description

Product Name:DARPP32 Rabbit mAb
Product Code:CAB4027
Size:20uL, 50uL, 100uL
Synonyms:DARPP-32, DARPP32
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human DARPP32
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human DARPP32
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84152
Uniprot:Q9UD71
Calculated MW:32kDa
Observed MW:32KDa
UniProt Protein Function:DARPP-32: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cell soma; cytoplasm; cytosol; nucleus

Molecular Function:D1 dopamine receptor binding; D2 dopamine receptor binding; D3 dopamine receptor binding; D4 dopamine receptor binding; D5 dopamine receptor binding; protein binding; protein kinase inhibitor activity; protein phosphatase inhibitor activity; protein phosphatase type 1 regulator activity; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: negative regulation of catalytic activity; negative regulation of female receptivity; regulation of catalytic activity; response to amphetamine; signal transduction; transcription, DNA-dependent; visual learning

NCBI Summary:This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q9UD71
NCBI GenInfo Identifier:23831292
NCBI Gene ID:84152
NCBI Accession:Q9UD71.2
UniProt Secondary Accession:Q9UD71,Q547V9, Q547W0, Q9H7G1,
UniProt Related Accession:Q9UD71
Molecular Weight:18,738 Da
NCBI Full Name:Protein phosphatase 1 regulatory subunit 1B
NCBI Synonym Full Names:protein phosphatase 1 regulatory inhibitor subunit 1B
NCBI Official Symbol:PPP1R1B  
NCBI Official Synonym Symbols:DARPP32; DARPP-32  
NCBI Protein Information:protein phosphatase 1 regulatory subunit 1B
UniProt Protein Name:Protein phosphatase 1 regulatory subunit 1B
UniProt Synonym Protein Names:DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoprotein
Protein Family:Protein phosphatase 1 regulatory
UniProt Gene Name:PPP1R1B  
UniProt Entry Name:PPR1B_HUMAN
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