Cell Death Antibodies 2

Anti-DAPK2 Antibody (CAB8199)

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SKU:
CAB8199
Product Type:
Antibody
Applications:
WB
Applications:
IF
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:DAPK2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8199
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human DAPK2 (NP_055141.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human DAPK2 (NP_055141.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VVNL ENFR KQYV RRRW KLSF SIVS LCNH LTRS LMKK VHLR PDED LRNC ESDT EEDI ARRK ALHP RRRS STS
Gene ID:23604
Uniprot:Q9UIK4
Cellular Location:Cytoplasm, Cytoplasmic vesicle, autophagosome lumen
Calculated MW:42kDa/55kDa
Observed MW:Refer to figures
Synonyms:DAPK2, DRP-1, DRP1
Background:This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.
UniProt Protein Function:DAPK2: an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle.
UniProt Protein Details:

Protein type:Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cytoplasm

Molecular Function:ATP binding; calmodulin binding; identical protein binding; protein binding; protein serine/threonine kinase activity

Biological Process: anoikis; apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy

NCBI Summary:This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UIK4
NCBI GenInfo Identifier:38605084
NCBI Gene ID:23604
NCBI Accession:Q9UIK4.1
UniProt Secondary Accession:Q9UIK4,O75892, Q24JS1, E9JGM7,
UniProt Related Accession:Q9UIK4
Molecular Weight:55,931 Da
NCBI Full Name:Death-associated protein kinase 2
NCBI Synonym Full Names:death associated protein kinase 2
NCBI Official Symbol:DAPK2  
NCBI Official Synonym Symbols:DRP1; DRP-1  
NCBI Protein Information:death-associated protein kinase 2
UniProt Protein Name:Death-associated protein kinase 2
UniProt Synonym Protein Names:DAP-kinase-related protein 1; DRP-1
Protein Family:Death-associated protein kinase
UniProt Gene Name:DAPK2  
UniProt Entry Name:DAPK2_HUMAN
Anti-DAPK2 Polyclonal Antibody (CAB8199)Immunofluorescence analysis of U2OS cells using DAPK2 antibody (CAB8199) at dilution of 1:100. Blue: DAPI for nuclear staining.
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