Anti-DAB2IP Antibody (CAB20493)

(No reviews yet) Write a Review
SKU:
CAB20493

Description

Product Name:DAB2IP Rabbit pAb
Product Code:CAB20493
Size:50uL, 100uL
Synonyms:AIP1, AIP-1, AF9Q34, DIP1/2
Applications:WB, IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human DAB2IP.
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Immunogen:Recombinant protein of human DAB2IP.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:153090
Uniprot:Q5VWQ8
Calculated MW:131kDa
Observed MW:Refer to Figures
UniProt Protein Function:Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively.
NCBI Summary:DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
UniProt Code:Q5VWQ8
NCBI GenInfo Identifier:94967023
NCBI Gene ID:153090
NCBI Accession:NP_115941.2
UniProt Secondary Accession:Q5VWQ8,Q8TDL2, Q96SE1, Q9C0C0, A6H8V2, A6NHI9, B0QZB1 G3XA90,
UniProt Related Accession:Q5VWQ8
Molecular Weight:Calculated MW: 106kDa/114kDa/117kDa/125kDa/131kDaObserved MW: 125kDa
NCBI Full Name:disabled homolog 2-interacting protein isoform 1
NCBI Synonym Full Names:DAB2 interacting protein
NCBI Official Symbol:DAB2IP  
NCBI Official Synonym Symbols:AIP1; AIP-1; AF9Q34; DIP1/2  
NCBI Protein Information:disabled homolog 2-interacting protein
UniProt Protein Name:Disabled homolog 2-interacting protein
UniProt Synonym Protein Names:ASK-interacting protein 1; AIP-1; DOC-2/DAB-2 interactive protein
Protein Family:Disabled homolog 2-interacting protein
UniProt Gene Name:DAB2IP  
UniProt Entry Name:DAB2P_HUMAN
View AllClose

Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AIP1
Synonyms:
AIP-1
Synonyms:
AF9Q34
Synonyms:
DIP1/2
View AllClose

Related Products