Anti-Cytokeratin 2e (KRT2) Antibody (CAB2615)
- SKU:
- CAB2615
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CK-2e
- Synonyms:
- K2e
- Synonyms:
- KRT2A
- Synonyms:
- KRT2E
- Synonyms:
- KRTE
- Research Area:
- Cell Biology
Description
| Product Name: | Cytokeratin 2e (KRT2) Rabbit mAb |
| Product Code: | CAB2615 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CK-2e, K2e, KRT2A, KRT2E, KRTE |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 2e (KRT2) |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431 |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 2e (KRT2) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3849 |
| Uniprot: | P35908 |
| Calculated MW: | 65kDa |
| Observed MW: | 65KDa |
| UniProt Protein Function: | K2: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: cornified envelope; cytosol; extracellular space; intermediate filament; membrane; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton; structural constituent of epidermis Biological Process: epidermis development; keratinization; keratinocyte activation; keratinocyte migration; keratinocyte proliferation; peptide cross-linking Disease: Ichthyosis, Bullous Type |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35908 |
| NCBI GenInfo Identifier: | 239938650 |
| NCBI Gene ID: | 3849 |
| NCBI Accession: | P35908.2 |
| UniProt Secondary Accession: | P35908,Q4VAQ2, |
| UniProt Related Accession: | P35908 |
| Molecular Weight: | 65kDa |
| NCBI Full Name: | Keratin, type II cytoskeletal 2 epidermal |
| NCBI Synonym Full Names: | keratin 2 |
| NCBI Official Symbol: | KRT2 |
| NCBI Official Synonym Symbols: | K2e; KRTE; CK-2e; KRT2A; KRT2E |
| NCBI Protein Information: | keratin, type II cytoskeletal 2 epidermal |
| UniProt Protein Name: | Keratin, type II cytoskeletal 2 epidermal |
| UniProt Synonym Protein Names: | Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT2 |
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