Cell Biology Antibodies 17
Anti-Cytokeratin 17 Antibody (CAB3769)
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- SKU:
- CAB3769
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Cytokeratin 17 Antibody |
| Antibody SKU: | CAB3769 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 17 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 17 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3872 |
| Uniprot: | Q04695 |
| Cellular Location: | |
| Calculated MW: | 48kDa |
| Observed MW: | 48KDa |
| Synonyms: | 39.1, CK-17, K17, PC, PC2, PCHC1 |
| Background: | This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008] |
| UniProt Protein Function: | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| NCBI Summary: | This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q04695 |
| NCBI GenInfo Identifier: | 547751 |
| NCBI Gene ID: | 3872 |
| NCBI Accession: | Q04695.2 |
| UniProt Secondary Accession: | Q04695,Q6IP98, Q8N1P6, A5Z1M9, A5Z1N0, A5Z1N1, A5Z1N2 A6NDV6, A6NKQ2, |
| UniProt Related Accession: | Q04695 |
| Molecular Weight: | 48,106 Da |
| NCBI Full Name: | Keratin, type I cytoskeletal 17 |
| NCBI Synonym Full Names: | keratin 17 |
| NCBI Official Symbol: | KRT17 |
| NCBI Official Synonym Symbols: | PC; K17; PC2; 39.1; CK-17; PCHC1 |
| NCBI Protein Information: | keratin, type I cytoskeletal 17 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 17 |
| UniProt Synonym Protein Names: | 39.1; Cytokeratin-17; CK-17; Keratin-17; K17 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT17 |
 | Western blot - Cytokeratin 17 Rabbit mAb (CAB3769) |
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