Anti-Cytokeratin 16 (KRT16) Antibody (CAB8690)

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SKU:
CAB8690
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CK16
Synonyms:
FNEPPK
Synonyms:
K16
Synonyms:
K1CP
Synonyms:
KRT16A
Synonyms:
NEPPK
Synonyms:
PC1
Research Area:
Cell Biology

Description

Product Name:Cytokeratin 16 (KRT16) Rabbit mAb
Product Code:CAB8690
Size:20uL, 50uL, 100uL
Synonyms:CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cytokeratin 16 (KRT16)
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse large intestine
Immunogen:A synthesized peptide derived from human Cytokeratin 16 (KRT16)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3868
Uniprot:P08779
Calculated MW:51kDa
Observed MW:50KDa
UniProt Protein Function:K16: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. K16 and K17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoskeleton; intermediate filament; nucleus

Molecular Function:protein binding; structural constituent of cytoskeleton

Biological Process: keratinocyte differentiation; cell proliferation; epidermis development; keratinization; morphogenesis of an epithelium; intermediate filament cytoskeleton organization and biogenesis; innate immune response; cytoskeleton organization and biogenesis; inflammatory response; negative regulation of cell migration; keratinocyte migration; hair cycle; aging

Disease: Palmoplantar Keratoderma, Nonepidermolytic, Focal; Pachyonychia Congenita 1

NCBI Summary:The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
UniProt Code:P08779
NCBI GenInfo Identifier:23503075
NCBI Gene ID:3868
NCBI Accession:P08779.4
UniProt Secondary Accession:P08779,P30654, Q16402, Q9UBG8, A8K488,
UniProt Related Accession:P08779
Molecular Weight:473
NCBI Full Name:Keratin, type I cytoskeletal 16
NCBI Synonym Full Names:keratin 16
NCBI Official Symbol:KRT16  
NCBI Official Synonym Symbols:K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A  
NCBI Protein Information:keratin, type I cytoskeletal 16; CK-16; keratin-16; cytokeratin 16; cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma
UniProt Protein Name:Keratin, type I cytoskeletal 16
UniProt Synonym Protein Names:Cytokeratin-16; CK-16; Keratin-16; K16
Protein Family:Keratin
UniProt Gene Name:KRT16  
UniProt Entry Name:K1C16_HUMAN
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