Anti-Cytokeratin 10 Antibody (CAB4669)
- SKU:
- CAB4669
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BCIE
- Synonyms:
- BIE
- Synonyms:
- CK10
- Synonyms:
- EHK
- Synonyms:
- K10
- Synonyms:
- KPP
- Research Area:
- Cell Biology
Description
| Product Name: | Cytokeratin 10 Rabbit mAb |
| Product Code: | CAB4669 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BCIE, BIE, CK10, EHK, K10, KPP |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 10 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, A-431 |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 10 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3858 |
| Uniprot: | P13645 |
| Calculated MW: | 60kDa |
| Observed MW: | 60KDa |
| UniProt Protein Function: | K10: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cytoplasm; extracellular space; membrane; nucleus Biological Process: keratinocyte differentiation Disease: Epidermolytic Hyperkeratosis; Erythroderma, Ichthyosiform, Congenital Reticular; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis |
| NCBI Summary: | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13645 |
| NCBI GenInfo Identifier: | 269849769 |
| NCBI Gene ID: | 3858 |
| NCBI Accession: | P13645.6 |
| UniProt Secondary Accession: | P13645,Q14664, Q8N175, |
| UniProt Related Accession: | P13645 |
| Molecular Weight: | 58,827 Da |
| NCBI Full Name: | Keratin, type I cytoskeletal 10 |
| NCBI Synonym Full Names: | keratin 10 |
| NCBI Official Symbol: | KRT10 |
| NCBI Official Synonym Symbols: | BIE; EHK; K10; KPP; BCIE; CK10 |
| NCBI Protein Information: | keratin, type I cytoskeletal 10 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 10 |
| UniProt Synonym Protein Names: | Cytokeratin-10; CK-10; Keratin-10; K10 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT10 |
| UniProt Entry Name: | K1C10_HUMAN |
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