Anti-Cytokeratin 1 (KRT1) Antibody (CAB9776)
- SKU:
- CAB9776
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CK1
- Synonyms:
- EHK
- Synonyms:
- EHK1
- Synonyms:
- EPPK
- Synonyms:
- K1
- Synonyms:
- KRT1A
- Synonyms:
- NEPPK
- Research Area:
- Cell Biology
Description
| Product Name: | Cytokeratin 1 (KRT1) Rabbit mAb |
| Product Code: | CAB9776 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 1 (KRT1) (KRT1) |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain, A375 |
| Immunogen: | A synthesized peptide derived from human Cytokeratin 1 (KRT1) (KRT1) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3848 |
| Uniprot: | P04264 |
| Cellular Location: | Cell membrane |
| Calculated MW: | 66kDa |
| Observed MW: | 70kDa |
| UniProt Protein Function: | K1: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: cytoskeleton; extracellular matrix; extracellular space; membrane; nucleus Molecular Function:carbohydrate binding; protein binding Biological Process: complement activation, lectin pathway; retinal homeostasis Disease: Epidermolytic Hyperkeratosis; Ichthyosis Hystrix, Curth-macklin Type; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis; Keratosis Palmoplantaris Striata Iii; Palmoplantar Keratoderma, Epidermolytic; Palmoplantar Keratoderma, Nonepidermolytic |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04264 |
| NCBI GenInfo Identifier: | 238054406 |
| NCBI Gene ID: | 3848 |
| NCBI Accession: | P04264.6 |
| UniProt Secondary Accession: | P04264,P85925, P86104, Q14720, Q6GSJ0, Q9H298, B2RA01 |
| UniProt Related Accession: | P04264 |
| Molecular Weight: | 66,039 Da |
| NCBI Full Name: | Keratin, type II cytoskeletal 1 |
| NCBI Synonym Full Names: | keratin 1 |
| NCBI Official Symbol: | KRT1 |
| NCBI Official Synonym Symbols: | K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK |
| NCBI Protein Information: | keratin, type II cytoskeletal 1 |
| UniProt Protein Name: | Keratin, type II cytoskeletal 1 |
| UniProt Synonym Protein Names: | 67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT1 |
| UniProt Entry Name: | K2C1_HUMAN |
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