KO Validated Antibodies 2

Anti-Cytochrome C [KO Validated] Antibody (CAB4912)

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SKU:
CAB4912
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CYC
Synonyms:
HCS
Synonyms:
THC4
Research Area:
Cell Death

Description

Product Name:[KO Validated] Cytochrome C Rabbit mAb
Product Code:CAB4912
Size:20uL, 50uL, 100uL
Synonyms:CYC, HCS, THC4
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cytochrome C
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, Mouse brain, Mouse kidney, Mouse heart, Rat brain, Rat kidney
Immunogen:A synthesized peptide derived from human Cytochrome C
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:54205
Uniprot:P99999
Cellular Location:Mitochondrion intermembrane space
Calculated MW:15kDa
Observed MW:14KDa
UniProt Protein Function:CYCS: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family.
UniProt Protein Details:

Protein type:Apoptosis; Oxidoreductase; Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 7p15.3

Cellular Component: cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus; protein phosphatase type 2A complex

Molecular Function:electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; heme binding; protein binding; protein serine/threonine phosphatase activity

Biological Process: caspase activation via cytochrome c; cellular respiration; mitochondrial electron transport, cytochrome c to oxygen; mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrion organization and biogenesis; response to reactive oxygen species

Disease: Thrombocytopenia 4

NCBI Summary:This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
UniProt Code:P99999
NCBI GenInfo Identifier:42560196
NCBI Gene ID:54205
NCBI Accession:P99999.2
UniProt Secondary Accession:P99999,P00001, Q6NUR2, Q6NX69, Q96BV4, A4D166, B2R4I1
UniProt Related Accession:P99999
Molecular Weight:11,749 Da
NCBI Full Name:Cytochrome c
NCBI Synonym Full Names:cytochrome c, somatic
NCBI Official Symbol:CYCS  
NCBI Official Synonym Symbols:CYC; HCS; THC4  
NCBI Protein Information:cytochrome c
UniProt Protein Name:Cytochrome c
Protein Family:Cytochrome
UniProt Gene Name:CYCS  
UniProt Entry Name:CYC_HUMAN
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