Cell Biology Antibodies 11
Anti-Cystatin-F Antibody (CAB8164)
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- SKU:
- CAB8164
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | CST7 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8164 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-145 of human CST7 (NP_003641.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-145 of human CST7 (NP_003641.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPSP DTCS QDLN SRVK PGFP KTIK TNDP GVLQ AARY SVEK FNNC TNDM FLFK ESRI TRAL VQIV KGLK YMLE VEIG RTTC KKNQ HLRL DDCD FQTN HTLK QTLS CYSE VWVV PWLQ HFEV PVLR CH |
| Gene ID: | 8530 |
| Uniprot: | O76096 |
| Cellular Location: | Cytoplasm, Secreted |
| Calculated MW: | 16kDa |
| Observed MW: | 16kDa |
| Synonyms: | CST7, CMAP |
| Background: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. |
| UniProt Protein Function: | CST7: Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. Belongs to the cystatin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: cytoplasm; extracellular region Molecular Function:protein binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity Biological Process: immune response |
| NCBI Summary: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76096 |
| NCBI GenInfo Identifier: | 262263314 |
| NCBI Gene ID: | 8530 |
| NCBI Accession: | |
| UniProt Secondary Accession: | O76096,Q6FH95, Q7Z4J8, Q9UED4, |
| UniProt Related Accession: | O76096 |
| Molecular Weight: | Calculated MW: 19kDaObserved MW: 19kDa |
| NCBI Full Name: | cystatin-F |
| NCBI Synonym Full Names: | cystatin F (leukocystatin) |
| NCBI Official Symbol: | CST7 |
| NCBI Official Synonym Symbols: | CMAP |
| NCBI Protein Information: | cystatin-F; cystatin-7; cystatin-like metastasis-associated protein; leukocystatin |
| UniProt Protein Name: | Cystatin-F |
| UniProt Synonym Protein Names: | Cystatin-7; Cystatin-like metastasis-associated protein; CMAP; Leukocystatin |
| Protein Family: | Cystatin |
| UniProt Gene Name: | CST7 |
| UniProt Entry Name: | CYTF_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CST7 antibody (CAB8164) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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