Neuroscience
Anti-CYSLTR1 Antibody (CAB1815)
- SKU:
- CAB1815
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-CYSLTR1 Antibody |
| Antibody SKU: | CAB1815 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CYSLTR1 (NP_006630.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-937, A-549, BxPC-3, HeLa, Mouse kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CYSLTR1 (NP_006630.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDET GNLT VSSA TCHD TIDD FRNQ VYST LYSM ISVV GFFG NGFV LYVL IKTY HKKS AFQV YMIN LAVA DLLC VCTL PLRV VYYV HKGI WLFG DFLC RLST |
| Gene ID: | 10800 |
| Uniprot: | Q9Y271 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 38kDa |
| Observed MW: | 38kDa |
| Synonyms: | CYSLTR1, CYSLT1, CYSLT1R, CYSLTR, HMTMF81 |
| Background: | This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: Xq13.2-q21.1 Cellular Component: membrane; plasma membrane Molecular Function:cysteinyl leukotriene receptor activity; leukotriene receptor activity; peptide receptor activity, G-protein coupled; protein binding Biological Process: circulatory system process; defense response; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neuropeptide signaling pathway; respiratory gaseous exchange |
| NCBI Summary: | This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9Y271 |
| NCBI GenInfo Identifier: | 20138087 |
| NCBI Gene ID: | 10800 |
| NCBI Accession: | Q9Y271.1 |
| UniProt Secondary Accession: | Q9Y271,Q5JS94, Q8IV19, B2R954, D3DTE4, |
| UniProt Related Accession: | Q9Y271 |
| Molecular Weight: | 38,541 Da |
| NCBI Full Name: | Cysteinyl leukotriene receptor 1 |
| NCBI Synonym Full Names: | cysteinyl leukotriene receptor 1 |
| NCBI Official Symbol: | CYSLTR1 |
| NCBI Official Synonym Symbols: | CYSLT1; CYSLTR; CYSLT1R; HMTMF81 |
| NCBI Protein Information: | cysteinyl leukotriene receptor 1 |
| UniProt Protein Name: | Cysteinyl leukotriene receptor 1 |
| UniProt Synonym Protein Names: | Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81 |
| Protein Family: | Cysteinyl leukotriene receptor |
| UniProt Gene Name: | CYSLTR1 |
| UniProt Entry Name: | CLTR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CYSLTR1 antibody (CAB1815) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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