Cell Biology Antibodies 2
Anti-CYR61 Antibody (CAB1111)
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- SKU:
- CAB1111
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CYR61 Antibody |
| Antibody SKU: | CAB1111 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CYR61 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, OVCAR3, HeLa, C2C12, Mouse heart, Mouse lung, Rat lung, Rat spleen |
| Immunogen: | Recombinant protein of human CYR61 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3491 |
| Uniprot: | O00622 |
| Cellular Location: | Secreted |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | CYR61, CCN1, GIG1, IGFBP10 |
| Background: | The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. |
| UniProt Protein Function: | CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1p22.3 Cellular Component: extracellular matrix; proteinaceous extracellular matrix Molecular Function:heparin binding; integrin binding; insulin-like growth factor binding; extracellular matrix binding Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; cell proliferation; positive regulation of osteoblast differentiation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; positive regulation of cell migration; negative regulation of apoptosis |
| NCBI Summary: | The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O00622 |
| NCBI GenInfo Identifier: | 3023601 |
| NCBI Gene ID: | 3491 |
| NCBI Accession: | O00622.1 |
| UniProt Secondary Accession: | O00622,O14934, O43775, Q9BZL7, |
| UniProt Related Accession: | O00622 |
| Molecular Weight: | |
| NCBI Full Name: | Protein CYR61 |
| NCBI Synonym Full Names: | cysteine-rich, angiogenic inducer, 61 |
| NCBI Official Symbol: | CYR61 |
| NCBI Official Synonym Symbols: | CCN1; GIG1; IGFBP10 |
| NCBI Protein Information: | protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10 |
| UniProt Protein Name: | Protein CYR61 |
| UniProt Synonym Protein Names: | CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1 |
| Protein Family: | Protein |
| UniProt Gene Name: | CYR61 |
| UniProt Entry Name: | CYR61_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CYR61 antibody (CAB1111) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunofluorescence analysis of L929 cells using CYR61 antibody (CAB1111) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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