Metabolism Antibodies 2
Anti-CYP4F12 Antibody (CAB7993)
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- SKU:
- CAB7993
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | CYP4F12 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7993 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 265-524 of human CYP4F12 (NP_076433.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse placenta, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 265-524 of human CYP4F12 (NP_076433.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DFTD AVIR ERRR TLPT QGID DFFK DKAK SKTL DFID VLLL SKDE DGKA LSDE DIRA EADT FMFG GHDT TASG LSWV LYNL ARHP EYQE RCRQ EVQE LLKD RDPK EIEW DDLA QLPF LTMC VKES LRLH PPAP FISR CCTQ DIVL PDGR VIPK GITC LIDI IGVH HNPT VWPD PEVY DPFR FDPE NSKG RSPL AFIP FSAG PRNC IGQA FAMA EMKV VLAL MLLH FRFL PDHT EPRR KLEL IMRA EGGL WLRV EPLN VSLQ |
| Gene ID: | 66002 |
| Uniprot: | Q9HCS2 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein |
| Calculated MW: | 11kDa/60kDa |
| Observed MW: | 60kDa |
| Synonyms: | CYP4F12, CYPIVF12, F22329_1 |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CYP4F12: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 1.14.13.30; Membrane protein, multi-pass; Oxidoreductase Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: apical plasma membrane; cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bound organelle Molecular Function:alkane 1-monooxygenase activity; arachidonic acid epoxygenase activity; leukotriene-B4 20-monooxygenase activity; oxygen binding Biological Process: arachidonic acid metabolic process; drug metabolic process; epoxygenase P450 pathway; long-chain fatty acid metabolic process; pressure natriuresis; renal water homeostasis; sodium ion homeostasis; very-long-chain fatty acid metabolic process; vitamin E metabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q9HCS2 |
| NCBI GenInfo Identifier: | 313104094 |
| NCBI Gene ID: | 66002 |
| NCBI Accession: | Q9HCS2.2 |
| UniProt Secondary Accession: | Q9HCS2,O60389, Q5JPJ7, Q9HCS1, E7ET51, |
| UniProt Related Accession: | Q9HCS2 |
| Molecular Weight: | 11,572 Da |
| NCBI Full Name: | Cytochrome P450 4F12 |
| NCBI Synonym Full Names: | cytochrome P450 family 4 subfamily F member 12 |
| NCBI Official Symbol: | CYP4F12 |
| NCBI Official Synonym Symbols: | CYPIVF12; F22329_1 |
| NCBI Protein Information: | cytochrome P450 4F12 |
| UniProt Protein Name: | Cytochrome P450 4F12 |
| UniProt Synonym Protein Names: | CYPIVF12 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP4F12 |
| UniProt Entry Name: | CP4FC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CYP4F12 antibody (CAB7993) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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