Cell Biology Antibodies 10
Anti-CYP4B1 Antibody (CAB6894)
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- SKU:
- CAB6894
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CYP4B1 Antibody |
| Antibody SKU: | CAB6894 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human CYP4B1 (NP_001093242.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human CYP4B1 (NP_001093242.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IHLL LRRQ TLAK AMDK FPGP PTHW LFGH ALEI QETG SLDK VVSW AHQF PYAH PLWF GQFI GFLN IYEP DYAK AVYS RGDP KAPD VYDF FLQW IGRG LLVL EGPK WLQH RKLL TPGF HYDV LKPY VAVF TEST RIML DKWE EKAR EGKS FDIF CDVG HMAL NTLM KCTF GRGD TGLG HSRD SSYY LAVS DLTL LMQQ RLVS FQYH NDFI YWLT PHGR RFLR A |
| Gene ID: | 1580 |
| Uniprot: | P13584 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| Calculated MW: | 58kDa/59kDa |
| Observed MW: | 59kDa |
| Synonyms: | CYP4B1, CYPIVB1, P-450HP |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. |
| UniProt Protein Function: | CYP4B1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.14.1; Oxidoreductase Chromosomal Location of Human Ortholog: 1p33 Cellular Component: endoplasmic reticulum membrane Molecular Function:iron ion binding; heme binding; drug binding; fluorene oxygenase activity; oxygen binding Biological Process: fluorene metabolic process; biphenyl metabolic process; xenobiotic metabolic process; exogenous drug catabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13584 |
| NCBI GenInfo Identifier: | 48429213 |
| NCBI Gene ID: | 1580 |
| NCBI Accession: | P13584.2 |
| UniProt Secondary Accession: | P13584,Q1HBI2, Q8TD85, Q8WWF2, Q8WWU9, Q8WWV0, |
| UniProt Related Accession: | P13584 |
| Molecular Weight: | 511 |
| NCBI Full Name: | Cytochrome P450 4B1 |
| NCBI Synonym Full Names: | cytochrome P450, family 4, subfamily B, polypeptide 1 |
| NCBI Official Symbol: | CYP4B1 |
| NCBI Official Synonym Symbols: | CYPIVB1; P-450HP |
| NCBI Protein Information: | cytochrome P450 4B1; cytochrome P450-HP; microsomal monooxygenase; cytochrome P450, subfamily IVB, polypeptide 1 |
| UniProt Protein Name: | Cytochrome P450 4B1 |
| UniProt Synonym Protein Names: | CYPIVB1; Cytochrome P450-HP |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP4B1 |
| UniProt Entry Name: | CP4B1_HUMAN |
 | Immunofluorescence analysis of HeLa cells using CYP4B1 antibody (CAB6894) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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