Metabolism Antibodies 1

Anti-CYP2J2 Antibody (CAB15045)

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SKU:
CAB15045
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-CYP2J2 Antibody
Antibody SKU:CAB15045
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP2J2 (NP_000766.2).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP2J2 (NP_000766.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RFEY QDSW FQQL LKLL DEVT YLEA SKTC QLYN VFPW IMKF LPGP HQTL FSNW KKLK LFVS HMID KHRK DWNP AETR DFID AYLK EMSK HTGN PTSS FHEE N
Gene ID:1573
Uniprot:P51589
Cellular Location:Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein
Calculated MW:57kDa
Observed MW:
Synonyms:CYP2J2, CPJ2, CYPIIJ2
Background:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene.
UniProt Protein Function:CYP2J2: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. Belongs to the cytochrome P450 family.
UniProt Protein Details:

Protein type:EC 1.14.14.1; Contractile; Oxidoreductase; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 1p31.3-p31.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function:arachidonic acid 11,12-epoxygenase activity; arachidonic acid 14,15-epoxygenase activity; arachidonic acid epoxygenase activity; monooxygenase activity; steroid hydroxylase activity

Biological Process: epoxygenase P450 pathway; icosanoid metabolic process; linoleic acid metabolic process; regulation of heart contraction; xenobiotic metabolic process

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
UniProt Code:P51589
NCBI GenInfo Identifier:21264413
NCBI Gene ID:1573
NCBI Accession:P51589.2
UniProt Secondary Accession:P51589,Q8TF13, B2RD33,
UniProt Related Accession:P51589
Molecular Weight:57,611 Da
NCBI Full Name:Cytochrome P450 2J2
NCBI Synonym Full Names:cytochrome P450 family 2 subfamily J member 2
NCBI Official Symbol:CYP2J2  
NCBI Official Synonym Symbols:CPJ2; CYPIIJ2  
NCBI Protein Information:cytochrome P450 2J2
UniProt Protein Name:Cytochrome P450 2J2
UniProt Synonym Protein Names:Arachidonic acid epoxygenase; CYPIIJ2
Protein Family:Cytochrome
UniProt Gene Name:CYP2J2  
UniProt Entry Name:CP2J2_HUMAN
Anti-CYP2J2 Antibody (CAB15045)Immunofluorescence analysis of HeLa cells using CYP2J2 antibody (CAB15045) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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