Anti-CYP26A1 Antibody (CAB5982)

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SKU:
CAB5982
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CP26
Synonyms:
CYP26
Synonyms:
P450RAI
Synonyms:
P450RAI1

Description

Product Name:CYP26A1 Rabbit mAb
Product Code:CAB5982
Size:20uL, 50uL, 100uL
Synonyms:CP26, CYP26, P450RAI, P450RAI1
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CYP26A1
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Rat liver
Immunogen:A synthesized peptide derived from human CYP26A1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1592
Uniprot:O43174
Calculated MW:50kDa
Observed MW:56KDa
UniProt Protein Function:CYP26A1: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Belongs to the cytochrome P450 family.
UniProt Protein Details:

Protein type:Cofactor and Vitamin Metabolism - retinol; EC 1.14.-.-; Oxidoreductase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: endoplasmic reticulum membrane

Molecular Function:oxygen binding; retinoic acid 4-hydroxylase activity; retinoic acid binding

Biological Process: metabolic process; negative regulation of retinoic acid receptor signaling pathway; vitamin metabolic process

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:O43174
NCBI GenInfo Identifier:218511987
NCBI Gene ID:1592
NCBI Accession:O43174.2
UniProt Secondary Accession:O43174,Q5VXH9, Q5VXI0, B3KNI4,
UniProt Related Accession:O43174
Molecular Weight:48,558 Da
NCBI Full Name:Cytochrome P450 26A1
NCBI Synonym Full Names:cytochrome P450 family 26 subfamily A member 1
NCBI Official Symbol:CYP26A1  
NCBI Official Synonym Symbols:CP26; CYP26; P450RAI; P450RAI1  
NCBI Protein Information:cytochrome P450 26A1
UniProt Protein Name:Cytochrome P450 26A1
UniProt Synonym Protein Names:Cytochrome P450 retinoic acid-inactivating 1; Cytochrome P450RAI; hP450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome
Protein Family:Cytochrome
UniProt Gene Name:CYP26A1  
UniProt Entry Name:CP26A_HUMAN
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