Signal Transduction Antibodies 2

Anti-CYP26A1 Antibody (CAB16259)

(No reviews yet) Write a Review
SKU:
CAB16259
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CYP26A1 Antibody
Antibody SKU:CAB16259
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CYP26A1 (NP_000774.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HepG2
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CYP26A1 (NP_000774.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GFPF FGET LQMV LQRR KFLQ MKRR KYGF IYKT HLFG RPTV RVMG ADNV RRIL LGEH RLVS VHWP ASVR TILG SGCL SNLH DSSH KQRK KVIM RAFS REAL E
Gene ID:1592
Uniprot:O43174
Cellular Location:
Calculated MW:48kDa/56kDa
Observed MW:55kDa
Synonyms:CYP26A1, CP26, CYP26, P450RAI, P450RAI1
Background:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.
UniProt Protein Function:CYP26A1: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Belongs to the cytochrome P450 family.
UniProt Protein Details:

Protein type:Cofactor and Vitamin Metabolism - retinol; EC 1.14.-.-; Oxidoreductase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: endoplasmic reticulum membrane

Molecular Function:oxygen binding; retinoic acid 4-hydroxylase activity; retinoic acid binding

Biological Process: metabolic process; negative regulation of retinoic acid receptor signaling pathway; vitamin metabolic process

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:O43174
NCBI GenInfo Identifier:218511987
NCBI Gene ID:1592
NCBI Accession:O43174.2
UniProt Secondary Accession:O43174,Q5VXH9, Q5VXI0, B3KNI4,
UniProt Related Accession:O43174
Molecular Weight:48,558 Da
NCBI Full Name:Cytochrome P450 26A1
NCBI Synonym Full Names:cytochrome P450 family 26 subfamily A member 1
NCBI Official Symbol:CYP26A1  
NCBI Official Synonym Symbols:CP26; CYP26; P450RAI; P450RAI1  
NCBI Protein Information:cytochrome P450 26A1
UniProt Protein Name:Cytochrome P450 26A1
UniProt Synonym Protein Names:Cytochrome P450 retinoic acid-inactivating 1; Cytochrome P450RAI; hP450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome
Protein Family:Cytochrome
UniProt Gene Name:CYP26A1  
UniProt Entry Name:CP26A_HUMAN
Anti-CYP26A1 Antibody (CAB16259)Western blot analysis of extracts of HepG2 cells, using CYP26A1 antibody (CAB16259) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
View AllClose

0 Reviews

View AllClose

Related Products

Human CYP26A1 ELISA Kit

Human CYP26A1 ELISA Kit

system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक