| Synonyms: | CYP1A1, AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX |
| Background: | This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | CYP1A1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450 Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: endoplasmic reticulum membrane; mitochondrion Molecular Function:oxidoreductase activity, acting on diphenols and related substances as donors; flavonoid 3'-monooxygenase activity; enzyme binding; iron ion binding; heme binding; oxidoreductase activity; steroid hydroxylase activity; oxygen binding; demethylase activity Biological Process: coumarin metabolic process; response to nematode; response to arsenic; response to lipopolysaccharide; cellular lipid metabolic process; response to vitamin A; response to antibiotic; embryonic development ending in birth or egg hatching; flavonoid metabolic process; porphyrin metabolic process; response to wounding; arachidonic acid metabolic process; drug metabolic process; aging; response to food; response to drug; insecticide metabolic process; camera-type eye development; response to iron(III) ion; response to virus; epoxygenase P450 pathway; response to herbicide; dibenzo-p-dioxin catabolic process; vitamin D metabolic process; cell proliferation; response to hyperoxia; gut development; xenobiotic metabolic process; maternal process involved in parturition; response to hypoxia; 9-cis-retinoic acid biosynthetic process; amine metabolic process; hydrogen peroxide biosynthetic process |
| NCBI Summary: | This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04798 |
| NCBI GenInfo Identifier: | 117139 |
| NCBI Gene ID: | 1543 |
| NCBI Accession: | P04798.1 |
| UniProt Secondary Accession: | P04798,Q53G18, A4F3V9, A4F3W0, |
| UniProt Related Accession: | P04798 |
| Molecular Weight: | 58kDa |
| NCBI Full Name: | Cytochrome P450 1A1 |
| NCBI Synonym Full Names: | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| NCBI Official Symbol: | CYP1A1Â Â |
| NCBI Official Synonym Symbols: | AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DXÂ Â |
| NCBI Protein Information: | cytochrome P450 1A1; CYPIA1; cytochrome P450-C; cytochrome P450-P1; cytochrome P450 form 6; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 |
| UniProt Protein Name: | Cytochrome P450 1A1 |
| UniProt Synonym Protein Names: | CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP1A1Â Â |
| UniProt Entry Name: | CP1A1_HUMAN |
