Metabolism Antibodies 1
Anti-CYP17A1 Antibody (CAB1373)
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- SKU:
- CAB1373
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-CYP17A1 Antibody |
| Antibody SKU: | CAB1373 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human CYP17A1 (NP_000093.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human CYP17A1 (NP_000093.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LSKD SLVD LVPW LKIF PNKT LEKL KSHV KIRN DLLN KILE NYKE KFRS DSIT NMLD TLMQ AKMN SDNG NAGP DQDS ELLS DNHI LTTI GDIF GAGV ETTT SVVK WTLA FLLH NPQV KKKL YEEI DQNV GFSR TPTI SDRN RLLL LEAT IREV LRLR PVAP MLIP HKAN VDSS IGEF AVDK GTEV IINL WALH HNEK EWHQ PDQF MPER FLNP AGTQ LISP SVSY LPFG AGPR SCIG EILA RQEL FLIM AWLL QRFD LEVP DDGQ LPSL EGIP KVVF LIDS FKVK IKVR QAWR EAQA EGST |
| Gene ID: | 1586 |
| Uniprot: | P05093 |
| Cellular Location: | Membrane |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
| Synonyms: | CYP17A1, CPT7, CYP17, P450C17, S17AH, 20 lyase |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17, 20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. |
| UniProt Code: | P05093 |
| NCBI GenInfo Identifier: | 117283 |
| NCBI Gene ID: | 1586 |
| NCBI Accession: | P05093.1 |
| UniProt Secondary Accession: | P05093,Q5TZV7, |
| UniProt Related Accession: | P05093 |
| Molecular Weight: | 57,371 Da |
| NCBI Full Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
| NCBI Synonym Full Names: | cytochrome P450 family 17 subfamily A member 1 |
| NCBI Official Symbol: | CYP17A1 |
| NCBI Official Synonym Symbols: | CPT7; CYP17; S17AH; P450C17 |
| NCBI Protein Information: | steroid 17-alpha-hydroxylase/17,20 lyase |
| UniProt Protein Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
| UniProt Synonym Protein Names: | 17-alpha-hydroxyprogesterone aldolase (EC:1.14.14.321 PublicationManual assertion based on experiment iniRef.10"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001."DeVore N.M., Scott E.E.Nature 482:116-119(2012) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 24-508 IN COMPLEXES WITH HEME; ABIRATERONE AND TOK-001, FUNCTION, CATALYTIC ACTIVITY, COFACTOR. |
| Protein Family: | Steroid 17-alpha-hydroxylase/17,20 lyase |
| UniProt Gene Name: | CYP17A1 |
 | Western blot analysis of extracts of rat testis, using CYP17A1 antibody (CAB1373) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of L929 cells using CYP17A1 antibody (CAB1373) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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