Cell Biology Antibodies 1
Anti-CYFIP1 Antibody (CAB10291)
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- SKU:
- CAB10291
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CYFIP1 Antibody |
| Antibody SKU: | CAB10291 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CYFIP1 (NP_055423.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | B cells, HepG2, HT-1080, Mouse lung, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CYFIP1 (NP_055423.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAQ VTLE DALS NVDL LEEL PLPD QQPC IEPP PSSL LYQP NFNT NFED RNAF VTGI ARYI EQAT VHSS MNEM LEEG QEYA VMLY TWRS CSRA IPQV KCNE QPNR VEIY EKTV EVLE PEVT KLMN FMYF QRNA IERF CGEV RRLC HAER RKDF VSEA YLIT LGKF INMF AVLD ELKN MKCS VKND HSAY KRAA QFLR KMAD PQSI QESQ NLSM FLAN HNKI TQSL QQQL EVIS GYEE LLAD IVNL CVDY YENR MYLT PSEK HMLL KVMG FG |
| Gene ID: | 23191 |
| Uniprot: | Q7L576 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, lamellipodium, perinuclear region, ruffle, synapse, synaptosome |
| Calculated MW: | 51kDa/94kDa/145kDa |
| Observed MW: | 145kDa |
| Synonyms: | CYFIP1, P140SRA-1, SHYC, SRA-1, SRA1 |
| Background: |
| UniProt Protein Function: | CYFIP1: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. Belongs to the CYFIP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 15q11.2 Cellular Component: cytosol; extracellular region; focal adhesion; lamellipodium; mRNA cap complex; neuron projection; perinuclear region of cytoplasm; ruffle Molecular Function:actin filament binding; protein binding; protein complex binding; Rac GTPase binding Biological Process: axon extension; cognition; lamellipodium biogenesis; neutrophil degranulation; Rac protein signal transduction; ruffle organization and biogenesis; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017] |
| UniProt Code: | Q7L576 |
| NCBI GenInfo Identifier: | 74738589 |
| NCBI Gene ID: | 23191 |
| NCBI Accession: | Q7L576.1 |
| UniProt Secondary Accession: | Q7L576,Q14467, Q5IED0, Q6ZSX1, Q9BSD9, Q9BVC7, A8K6D9 |
| UniProt Related Accession: | Q7L576 |
| Molecular Weight: | 145kDa |
| NCBI Full Name: | Cytoplasmic FMR1-interacting protein 1 |
| NCBI Synonym Full Names: | cytoplasmic FMR1 interacting protein 1 |
| NCBI Official Symbol: | CYFIP1 |
| NCBI Official Synonym Symbols: | SHYC; SRA1; SRA-1; P140SRA-1 |
| NCBI Protein Information: | cytoplasmic FMR1-interacting protein 1 |
| UniProt Protein Name: | Cytoplasmic FMR1-interacting protein 1 |
| UniProt Synonym Protein Names: | Specifically Rac1-associated protein 1; Sra-1; p140sra-1 |
| Protein Family: | Cytoplasmic FMR1-interacting protein |
| UniProt Gene Name: | CYFIP1 |
 | Western blot analysis of extracts of various cell lines, using CYFIP1 antibody (CAB10291) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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