Cell Biology Antibodies 17
Anti-Cyclophilin B Antibody (CAB4861)
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- SKU:
- CAB4861
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CYP-S1
- Synonyms:
- CYPB
- Synonyms:
- HEL-S-39
- Synonyms:
- OI9
- Synonyms:
- SCYLP
- Research Area:
- Cell Biology
Description
| Product Name: | Cyclophilin B Rabbit mAb |
| Product Code: | CAB4861 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CYP-S1, CYPB, HEL-S-39, OI9, SCYLP |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cyclophilin B |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HT-29, HepG2, Mouse liver, Mouse kidney, Mouse pancreas, Rat lung, Rat liver, Rat spleen |
| Immunogen: | A synthesized peptide derived from human Cyclophilin B |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5479 |
| Uniprot: | P23284 |
| Cellular Location: | Endoplasmic reticulum lumen, Melanosome |
| Calculated MW: | 18kDa |
| Observed MW: | 19KDa |
| UniProt Protein Function: | PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; Chaperone; EC 5.2.1.8; Secreted; Cyclophilin; Secreted, signal peptide; RNA-binding Chromosomal Location of Human Ortholog: 15q21-q22 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; melanosome; membrane; nucleus; perinuclear region of cytoplasm; smooth endoplasmic reticulum Molecular Function:collagen binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding Biological Process: extracellular matrix organization and biogenesis; positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization Disease: Osteogenesis Imperfecta, Type Ix |
| NCBI Summary: | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P23284 |
| NCBI GenInfo Identifier: | 215273869 |
| NCBI Gene ID: | 5479 |
| NCBI Accession: | P23284.2 |
| UniProt Secondary Accession: | P23284,Q6IBH5, Q9BVK5, A8K534, |
| UniProt Related Accession: | P23284 |
| Molecular Weight: | 23,743 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase B |
| NCBI Synonym Full Names: | peptidylprolyl isomerase B |
| NCBI Official Symbol: | PPIB |
| NCBI Official Synonym Symbols: | OI9; CYPB; SCYLP; CYP-S1; HEL-S-39 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase B |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase B |
| UniProt Synonym Protein Names: | CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
| Protein Family: | Probable peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIB |
| UniProt Entry Name: | PPIB_HUMAN |
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