Epigenetics & Nuclear Signaling Antibodies 2
Anti-Cyclin L2 Antibody (CAB14938)
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- SKU:
- CAB14938
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Cyclin L2 Antibody |
| Antibody SKU: | CAB14938 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-150 of human Cyclin L2 (NP_001307082.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG, HeLa, Jurkat, A375, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-150 of human Cyclin L2 (NP_001307082.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QLYA RKKV DLTH LEGE VEKR KHAI EEAK AQAR GLLP GGTQ VLDG TSGF SPAP KLVE SPKE GKGS KPSP LSVK NTKR RLEG AKKA KADS PVN |
| Gene ID: | 81669 |
| Uniprot: | Q96S94 |
| Cellular Location: | Nucleus speckle |
| Calculated MW: | 24kDa/25kDa/33kDa/58kDa |
| Observed MW: | 58kDa |
| Synonyms: | CCNL2, ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE, SB138, cyclin-L2 |
| Background: | The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | CCNL2: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis. Belongs to the cyclin family. Cyclin L subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Transcription regulation Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: cyclin-dependent protein kinase holoenzyme complex; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:cyclin-dependent protein kinase regulator activity; protein binding Biological Process: positive regulation of cyclin-dependent protein kinase activity; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q96S94 |
| NCBI GenInfo Identifier: | 74752124 |
| NCBI Gene ID: | 81669 |
| NCBI Accession: | Q96S94.1 |
| UniProt Secondary Accession: | Q96S94,Q5T2N5, Q5T2N6, Q6IQ12, A0A024R072, A0A024R077, A0A0C4DGC4 A8K8A3, B1B152, F2Z3J5, |
| UniProt Related Accession: | Q96S94 |
| Molecular Weight: | 24,621 Da |
| NCBI Full Name: | Cyclin-L2 |
| NCBI Synonym Full Names: | cyclin L2 |
| NCBI Official Symbol: | CCNL2 |
| NCBI Official Synonym Symbols: | CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO |
| NCBI Protein Information: | cyclin-L2 |
| UniProt Protein Name: | Cyclin-L2 |
| UniProt Synonym Protein Names: | Paneth cell-enhanced expression protein |
| Protein Family: | Cyclin |
| UniProt Gene Name: | CCNL2 |
| UniProt Entry Name: | CCNL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Cyclin L2 antibody (CAB14938) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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