Cell Cycle Antibodies 1
Anti-Cyclin K Antibody (CAB10261)
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- SKU:
- CAB10261
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-Cyclin K Antibody |
| Antibody SKU: | CAB10261 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Cyclin K (NP_001092872.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Cyclin K (NP_001092872.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKEN KENS SPSV TSAN LDHT KPCW YWDK KDLA HTPS QLEG LDPA TEAR YRRE GARF IFDV GTRL GLHY DTLA TGII YFHR FYMF HSFK QFPR YVTG ACCL FLAG KVEE TPKK CKDI IKTA RSLL NDVQ FGQF GDDP KEEV MVLE RILL QTIK FDLQ VEHP |
| Gene ID: | 8812 |
| Uniprot: | O75909 |
| Cellular Location: | Nucleus |
| Calculated MW: | 40kDa/41kDa/64kDa/66kDa |
| Observed MW: | 90kDa |
| Synonyms: | CCNK, CPR4, cyclin-K |
| Background: | The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. |
| UniProt Protein Function: | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). |
| NCBI Summary: | The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75909 |
| NCBI GenInfo Identifier: | 218511966 |
| NCBI Gene ID: | 8812 |
| NCBI Accession: | O75909.2 |
| UniProt Secondary Accession: | O75909,Q59FT6, Q86U16, Q96B63, Q9NNY9, |
| UniProt Related Accession: | O75909 |
| Molecular Weight: | 64kDa |
| NCBI Full Name: | Cyclin-K |
| NCBI Synonym Full Names: | cyclin K |
| NCBI Official Symbol: | CCNK |
| NCBI Official Synonym Symbols: | CPR4 |
| NCBI Protein Information: | cyclin-K |
| UniProt Protein Name: | Cyclin-K |
| Protein Family: | Cyclin |
| UniProt Gene Name: | CCNK |
 | Western blot analysis of extracts of various cell lines, using Cyclin K Antibody (CAB10261) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using Cyclin K Rabbit pAb (CAB10261) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spinal cord using Cyclin K Rabbit pAb (CAB10261) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using Cyclin K Rabbit pAb (CAB10261) at dilution of 1:100 (40x lens). |
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