Cell Cycle Antibodies 1
Anti-Cyclin G1 Antibody (CAB5292)
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- SKU:
- CAB5292
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-Cyclin G1 Antibody |
| Antibody SKU: | CAB5292 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human Cyclin G1 (NP_004051.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:20 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse skeletal muscle |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human Cyclin G1 (NP_004051.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PSVL ALSI IALE IQAQ KCVE LTEG IECL QKHS KING RDLT FWQE LVSK CLTE YSSN KCSK PNVQ KLKW IVSG RTAR QLKH SYYR ITHL PTIP EMVP |
| Gene ID: | 900 |
| Uniprot: | P51959 |
| Cellular Location: | Nucleus |
| Calculated MW: | 18kDa/34kDa |
| Observed MW: | 34kDa |
| Synonyms: | CCNG1, CCNG, cyclin-G1 |
| Background: | The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. |
| UniProt Protein Function: | CCNG1: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. Belongs to the cyclin family. Cyclin G subfamily. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 5q32-q34 Cellular Component: nucleoplasm Molecular Function:protein binding Biological Process: regulation of cyclin-dependent protein kinase activity |
| NCBI Summary: | The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51959 |
| NCBI GenInfo Identifier: | 2506334 |
| NCBI Gene ID: | 900 |
| NCBI Accession: | P51959.2 |
| UniProt Secondary Accession: | P51959,Q15757, Q96L32, B2R7B2, B4DLW7, D3DQK7, |
| UniProt Related Accession: | P51959 |
| Molecular Weight: | 18,769 Da |
| NCBI Full Name: | Cyclin-G1 |
| NCBI Synonym Full Names: | cyclin G1 |
| NCBI Official Symbol: | CCNG1 |
| NCBI Official Synonym Symbols: | CCNG |
| NCBI Protein Information: | cyclin-G1 |
| UniProt Protein Name: | Cyclin-G1 |
| Protein Family: | Cyclin |
| UniProt Gene Name: | CCNG1 |
| UniProt Entry Name: | CCNG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Cyclin G1 antibody (CAB5292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat testis using Cyclin G1 antibody (CAB5292) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using Cyclin G1 antibody (CAB5292) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of 293T cells using Cyclin G1 antibody (CAB5292) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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