Cell Biology Antibodies 13

Anti-CYBRD1 Antibody (CAB17215)

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SKU:
CAB17215
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CYBRD1 Antibody
Antibody SKU:CAB17215
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 215-286 of human CYBRD1 (NP_079119.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29, A-431
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 215-286 of human CYBRD1 (NP_079119.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IFWI VTRP QWKR PKEP NSTI LHPN GGTE QGAR GSMP AYSG NNMD KSDS ELNS EVAA RKRN LALD EAGQ RSTM
Gene ID:79901
Uniprot:Q53TN4
Cellular Location:
Calculated MW:
Observed MW:36kDa
Anti-CYBRD1 Antibody (CAB17215)Western blot - CYBRD1 Rabbit pAb (CAB17215)
Synonyms:CYBRD1, CYB561A2, CYBRD1
Background:This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption.
UniProt Protein Function:CYBRD1: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass; EC 1.-.-.-; Transporter, iron; Oxidoreductase

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: brush border membrane; integral to membrane; plasma membrane

Molecular Function:oxidoreductase activity, oxidizing metal ions; metal ion binding; ferric-chelate reductase activity

Biological Process: cellular iron ion homeostasis; response to iron ion; transmembrane transport

NCBI Summary:This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]
UniProt Code:Q53TN4
NCBI GenInfo Identifier:74726934
NCBI Gene ID:79901
NCBI Accession:Q53TN4.1
UniProt Secondary Accession:Q53TN4,Q6KC16, Q6KC17, Q6P147, Q6ZR51, Q9H0Q8, Q9H5G5 B2RE79, B4DWD7,
UniProt Related Accession:Q53TN4
Molecular Weight:25,087 Da
NCBI Full Name:Cytochrome b reductase 1
NCBI Synonym Full Names:cytochrome b reductase 1
NCBI Official Symbol:CYBRD1  
NCBI Official Synonym Symbols:DCYTB; FRRS3; CYB561A2  
NCBI Protein Information:cytochrome b reductase 1; duodenal cytochrome b; ferric-chelate reductase 3; cytochrome b561 family, member A2
UniProt Protein Name:Cytochrome b reductase 1
UniProt Synonym Protein Names:Duodenal cytochrome b; Ferric-chelate reductase 3
Protein Family:Cytochrome b reductase
UniProt Gene Name:CYBRD1  
UniProt Entry Name:CYBR1_HUMAN
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