Immunology Antibodies 3

Anti-CXCR5 Antibody (CAB8950)

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SKU:
CAB8950
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CXCR5 Antibody
Antibody SKU:CAB8950
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CXCR5
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, K-562, Mouse lung, Mouse spleen, Mouse thymus, Rat thymus
Immunogen:A synthesized peptide derived from human CXCR5
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:643
Uniprot:P32302
Cellular Location:
Calculated MW:42kDa
Observed MW:45KDa
Synonyms:BLR1, CD185, MDR15
Background:This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Protein Function:CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:G-protein coupled receptor activity; protein binding; C-X-C chemokine receptor activity

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; B cell activation; immune response; cell motility; chemotaxis; lymph node development

NCBI Summary:This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:P32302
NCBI GenInfo Identifier:416718
NCBI Gene ID:643
NCBI Accession:P32302.1
UniProt Related Accession:P32302
Molecular Weight:
NCBI Full Name:C-X-C chemokine receptor type 5
NCBI Synonym Full Names:C-X-C motif chemokine receptor 5
NCBI Official Symbol:CXCR5  
NCBI Official Synonym Symbols:BLR1; CD185; MDR15  
NCBI Protein Information:C-X-C chemokine receptor type 5
UniProt Protein Name:C-X-C chemokine receptor type 5
UniProt Synonym Protein Names:Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD_antigen: CD185
UniProt Gene Name:CXCR5  
UniProt Entry Name:CXCR5_HUMAN
Anti-CXCR5 Antibody (CAB8950)Western blot - CXCR5 Rabbit mAb (CAB8950)
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